Soltani Moghadam Reza, Akbari Mitra, Rouhani Parisa, Medghalchi Abdolreza, Leili Ehsan Kazemnezhad, Azaripour Ebrahim
Eye Research Center, Eye Department, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Oman J Ophthalmol. 2025 Jun 24;18(2):144-149. doi: 10.4103/ojo.ojo_236_23. eCollection 2025 May-Aug.
Determination of the normal range of corneal epithelial thickness (CET) profiles in different populations is important. Accordingly, the present study aimed to investigate the CET in normal eyes in Guilan province of Iran.
In this cross-sectional study, a total of 169 patients (18-60 years old) who were referred to the ophthalmology clinics in Rasht for corneal refractive surgery were included. They underwent a complete ophthalmological examination, including visual acuity, intraocular pressure examination, and fundoscopy examination with a 90 D lens. Spectral-domain optical coherence tomography was used to examine CET; corneal epithelial mapping was done with Optovue I scan 500s.
The mean CET at 5-6 mm and 2-5 mm zones was 52.88 ± 2.8 and 53.24 ± 2.9, in the 2 mm of the center was 53.67 ± 3.24, in the superior and inferior 5-6 mm zone was 50.8 ± 3.18 and 54.38 ± 3.53, and in superior and inferior 2-5 mm zone was 52.14 ± 2.98 and 54.41 ± 3.60, respectively; there was a significant difference between 5-6 and 2-5 mm of the superior zone. The supratemporal region had the thinnest epithelium, and the inferior region had the thickest. The central CET was statistically different between males and females, and the relationship between paracentral and peripheral thickness (2-5 and 5-6 mm) with age, especially in ages 33-46 and 47-60, was stronger.
The values of the CET map, defined in the present study, in a sample of Guilan population with normal eyes, can be further used as a reference (normal) range for this population.
确定不同人群角膜上皮厚度（CET）分布的正常范围很重要。因此，本研究旨在调查伊朗吉兰省正常眼的CET。
在这项横断面研究中，纳入了总共169例（年龄在18至60岁之间）因角膜屈光手术转诊至拉什特眼科诊所的患者。他们接受了全面的眼科检查，包括视力、眼压检查以及使用90D透镜进行的眼底镜检查。采用频域光学相干断层扫描来检查CET；使用Optovue I scan 500s进行角膜上皮地形图绘制。
5 - 6mm和2 - 5mm区域的平均CET分别为52.88±2.8和53.24±2.9，中心2mm处为53.67±3.24，上方和下方5 - 6mm区域分别为50.8±3.18和54.38±3.53，上方和下方2 - 5mm区域分别为52.14±2.98和54.41±3.60；上方区域的5 - 6mm和2 - 5mm之间存在显著差异。颞上区域的上皮最薄，下方区域的上皮最厚。中心CET在男性和女性之间存在统计学差异，旁中心和周边厚度（2 - 5mm和5 - 6mm）与年龄的关系更强，尤其是在33 - 46岁和47 - 60岁年龄段。
本研究确定的CET图谱值，在吉兰省正常眼样本中，可进一步用作该人群的参考（正常）范围。
