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人体主动脉模型中通过人工瓣膜的生理性搏动血流的实验研究——II. 倾斜盘式瓣膜及其取向的影响

Experimental study of physiological pulsatile flow past valve prosthesis in a model of human aorta--II. Tilting disc valves and the effect of orientation.

作者信息

Chandran K B, Khalighi B, Chen C J

出版信息

J Biomech. 1985;18(10):773-80. doi: 10.1016/0021-9290(85)90052-1.

DOI:10.1016/0021-9290(85)90052-1
PMID:4066720
Abstract

In Part II of this two paper sequence, pulsatile flow development past a tilting disc valve in a model human aorta has been studied using quantitative laser Doppler techniques. The valve was mounted in three different orientations with respect to the aortic root in this study. Under pulsatile flow, the region of flow reversal induced near the wall of the minor flow orifice extends to more than one tissue annulus diameter downstream from the valve into the ascending aorta. In a plane perpendicular to the tilt axis, a bi-helical secondary flow is induced distal to the valve. This secondary flow is further compounded by the multiple curvatures in the aorta. Hence the valve orientation affects the velocity profiles as far downstream as the mid-arch region as well as in the brachio-cephalic arterial branch. In the mid-arch region, a flow reversal along the entire cross-section is observed in early diastole for all the three orientations of the disc valve.

摘要

在这两篇论文系列的第二部分中,使用定量激光多普勒技术研究了在模拟人体主动脉中经过倾斜盘形瓣膜的脉动流发展情况。在本研究中,瓣膜相对于主动脉根部以三种不同方向安装。在脉动流下,小流量孔壁附近诱导的流动逆转区域从瓣膜向下游延伸到升主动脉中超过一个组织环直径的位置。在垂直于倾斜轴的平面中,在瓣膜远端诱导出双螺旋二次流。主动脉中的多个曲率进一步加剧了这种二次流。因此,瓣膜方向会影响远至主动脉弓中部区域以及头臂动脉分支处的速度分布。在主动脉弓中部区域,对于盘形瓣膜的所有三种方向,在舒张早期均观察到沿整个横截面的流动逆转。

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Experimental study of physiological pulsatile flow past valve prosthesis in a model of human aorta--II. Tilting disc valves and the effect of orientation.人体主动脉模型中通过人工瓣膜的生理性搏动血流的实验研究——II. 倾斜盘式瓣膜及其取向的影响
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