Ricketts W G, Birchenall-Sparks M C, Hardwick J P, Richardson A
J Cell Physiol. 1985 Dec;125(3):492-8. doi: 10.1002/jcp.1041250319.
The influence of age and food restriction on kidney protein synthesis was studied in Fischer F344 rats. The rate of total protein synthesis by suspensions of kidney cells declined 60% between 4 and 31 months of age. The rate of protein synthesis by kidney cells isolated from 19-month old rats fed a restricted diet (60% of diet consumed by rats fed ad libitum) was 45% higher than the rate of protein synthesis by kidney cells isolated from 19-month old rats fed ad libitum. The excretion of protein in the urine was measured to assess the effect of the age related decline in protein synthesis on kidney function. A dramatic increase in proteinuria was observed with increasing age, and rats fed the restricted diet excreted significantly less protein in the urine than rats fed ad libitum.
在Fischer F344大鼠中研究了年龄和食物限制对肾脏蛋白质合成的影响。肾细胞悬液的总蛋白质合成速率在4至31月龄之间下降了60%。从自由采食的19月龄大鼠中分离出的肾细胞的蛋白质合成速率，比从限食（自由采食大鼠食量的60%）的19月龄大鼠中分离出的肾细胞的蛋白质合成速率高45%。测量尿蛋白排泄量以评估蛋白质合成随年龄下降对肾功能的影响。随着年龄增长，蛋白尿显著增加，且限食大鼠的尿蛋白排泄量明显低于自由采食大鼠。
