Prados-Carmona Alvaro, Husein-ElAhmed Husein, Navarro-Triviño Francisco J, Ruiz-Villaverde Ricardo
Department of Dermatology, Hospital Universitario San Cecilio, Avenida de la Ilustración S/N, 18016, Granada, Spain.
Instituto Biosanitario de Granada,, Granada, Ibs, Spain.
Clin Rev Allergy Immunol. 2025 Jul 16;68(1):66. doi: 10.1007/s12016-025-09075-w.
Atopic dermatitis is the most prevalent chronic inflammatory skin disease, traditionally recognized for its defining eczematous lesions. However, the implications of atopic dermatitis extend far beyond eczema itself. Increasing understanding of the disease has enabled a more accurate characterization of its burden, including structural and functional skin alterations as well as various systemic comorbidities. This review examines the impact of the disease, beginning with the neuroimmune pathways underlying pruritus and its psychosocial burden, and progressing to the current concepts surrounding the atopic march and the broader spectrum of inflammatory or immune-mediated non-atopic comorbidities, including the emerging discussion on its similarities and differences with psoriasis. Special attention has been given to literature published from 2015 onwards. Ultimately, this review aims to deepen the understanding of the systemic nature of atopic dermatitis, providing a broader conceptual framework for assessing disease extent and severity.
特应性皮炎是最常见的慢性炎症性皮肤病，传统上以其典型的湿疹样皮损而被认可。然而，特应性皮炎的影响远不止湿疹本身。对该疾病认识的不断加深，使其负担的特征描述更加准确，包括皮肤结构和功能改变以及各种系统性合并症。本综述探讨了该疾病的影响，首先从瘙痒的神经免疫途径及其心理社会负担入手，进而阐述了围绕特应性进程以及更广泛的炎症或免疫介导的非特应性合并症的当前概念，包括关于其与银屑病异同的新讨论。特别关注了2015年以来发表的文献。最终，本综述旨在加深对特应性皮炎系统性本质的理解，为评估疾病范围和严重程度提供更广泛的概念框架。
