Liang ZuanLei, Shan Guangcun, Shan Shizhe, Ding Zejian, Zhang Jiliang, Chu Bingfeng
Shenzhen Nanshan People's Hospital, Shenzhen 518052, China.
DATAXYZ Hong Kong Co. Ltd., Kowloon, Hong Kong Special Administrative Region of China; College of Engineering, City University of Hong Kong, Hong Kong Special Administrative Regions; Beijing Advanced Innovation Center for Big Data-based Precision Medicine & School of Instrumentation Science and Opto-electronics Engineering, Beihang University, Beijing 100083, China.
Int J Pharm. 2025 Sep 15;682:125970. doi: 10.1016/j.ijpharm.2025.125970. Epub 2025 Jul 14.
Since its emergence in China in December 2019, the outbreak of COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has escalated into a global pandemic emergency, demanding immediate and coordinated international action. This comprehensive review offers a broad, interdisciplinary perspective, exploring how advancements in nanotechnologies can aid in the battle against COVID-19 and other infectious diseases, with an emphasis on future pandemic preparedness. By analyzing the virus's life cycle, we identify key points where nanotechnology can be effective. Nanoparticles (NPs) can inactivate viruses through photothermal or photocatalysis-induced reactive oxygen species generation, offering potential healthcare applications. Nanotechnology can also revolutionize diagnostics by creating simple, rapid, and cost-effective assays for SARS-CoV-2 detection. Additionally, it can facilitate targeted drug delivery to the lungs, disrupting the interaction between ACE2 receptors and the viral S protein. Furthermore, the exemplary innovative strategies pertinent to nanomaterials in antiviral research on SARS-CoV-2 are also concisely recapped with a primary focus on interrupting the virus's life cycle to effectively combat it. In conclusion, emerging nanotechnologies stands as a vital tool in the fight against COVID-19 and will be indispensable in preparing for and mitigating the impact of future pandemics.
自2019年12月在中国出现以来，由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的COVID-19疫情已升级为全球大流行紧急情况，需要立即采取协调一致的国际行动。这篇全面综述提供了一个广泛的跨学科视角，探讨纳米技术的进展如何有助于抗击COVID-19和其他传染病，并着重于未来的大流行防范。通过分析病毒的生命周期，我们确定了纳米技术可能有效的关键点。纳米颗粒（NPs）可以通过光热或光催化诱导产生活性氧来使病毒失活，具有潜在的医疗应用价值。纳米技术还可以通过创建用于SARS-CoV-2检测的简单、快速且经济高效的检测方法来彻底改变诊断方式。此外，它可以促进向肺部的靶向药物递送，破坏ACE2受体与病毒S蛋白之间的相互作用。此外，还简要回顾了与纳米材料在SARS-CoV-2抗病毒研究中相关的典型创新策略，主要侧重于中断病毒的生命周期以有效对抗它。总之，新兴的纳米技术是抗击COVID-19的重要工具，在为未来大流行做准备和减轻其影响方面将不可或缺。
