Zhang Miaohe, Feng Shuang, Song Junrong, Xue Wei
State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals, Guizhou University, Guiyang 550025, P.R. China.
School of Chemical Engineering, Guizhou Institute of Technology, Guiyang 550025, P.R. China.
J Agric Food Chem. 2025 Jul 30;73(30):18680-18690. doi: 10.1021/acs.jafc.5c05073. Epub 2025 Jul 16.
The present study involved the development of a series of novel antibacterial compounds based on the structure of the natural product formononetin. The activity experiments demonstrated that compound exhibited the most potent inhibitory effects against () and pv citri (), with EC values of 0.9 and 2.4 μg/mL, respectively. Pot experiments verified the excellent curative and protective effects of against bacterial leaf blight of rice () and citrus canker (). Furthermore, a series of physiological and biochemical experiments were conducted to investigate the action mechanism exerted by against plant pathogens and . The findings revealed that effectively inhibited the expression of multiple pathogenic factors, disrupted their energy metabolism, altered their cell membrane morphology, enhanced the activity of host defense enzymes, and attenuated their virulence toward host cells. Therefore, could serve as a promising candidate drug for the inhibition of crop pathogens.
本研究涉及基于天然产物芒柄花素的结构开发一系列新型抗菌化合物。活性实验表明，该化合物对水稻白叶枯病菌（Xanthomonas oryzae pv. oryzae）和柑橘溃疡病菌（Xanthomonas axonopodis pv. citri）表现出最有效的抑制作用，其EC值分别为0.9和2.4 μg/mL。盆栽实验验证了该化合物对水稻白叶枯病（Xanthomonas oryzae pv. oryzae）和柑橘溃疡病（Xanthomonas axonopodis pv. citri）具有优异的治疗和保护作用。此外，还进行了一系列生理生化实验，以研究该化合物对植物病原菌水稻白叶枯病菌（Xanthomonas oryzae pv. oryzae）和柑橘溃疡病菌（Xanthomonas axonopodis pv. citri）的作用机制。研究结果表明，该化合物有效抑制了多种致病因子的表达，破坏了它们的能量代谢，改变了它们的细胞膜形态，增强了宿主防御酶的活性，并减弱了它们对宿主细胞的毒力。因此，该化合物可作为一种有前景的抑制作物病原菌的候选药物。
