Zhang Hongkang, Zhang Yang, Sheng Lili, Cao Xiaofeng, Wu Chuanjie, Song Baoying, Shen Yunong, Xu Zikai, Song Ge, Sun Hao, Liu Qing, Ji Xunming, Jiang Miaowen, Li Ming, Zheng Yufeng
School of Materials Science and Engineering, Peking University, Beijing, China.
China-America Institute of Neuroscience and and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.
Nat Commun. 2025 Jul 16;16(1):6557. doi: 10.1038/s41467-025-61199-x.
Most acute ischemic stroke patients with large vessel occlusion require stent implantation post-thrombectomy for complete recanalization, yet they exhibit a high rate of poor prognosis due to ischemia-reperfusion injury. Thus, combining reperfusion therapy with neuroprotective treatment offers significant advantages. This study introduces a novel Mg eluting stent by incorporating neuroprotective MgSO particles into a PLCL (poly (l-lactide-co-ε-caprolactone)) substrate using 3D printing technology. A novel MgSO-particle/Mg-ions combined-mechanical reinforcement mechanism was introduced. Subsequently, the neuroprotective efficacy of the stents was validated through oxygen-glucose deprivation/reoxygenation-injured neuron cells in vitro and via the transient middle cerebral artery occlusion rat model to emulate human brain ischemia/reperfusion injury in vivo. The staged-release of Mg is supposed to provide sequential neuroprotection that aligns with the treatment window for acute ischemic stroke. This study marks the first development of biodegradable neuroprotective brain stents and presents an effective strategy to alleviate cerebral ischemia-reperfusion injury.
大多数患有大血管闭塞的急性缺血性中风患者在血栓切除术后需要进行支架植入以实现完全再通，但由于缺血再灌注损伤，他们的预后较差。因此，将再灌注治疗与神经保护治疗相结合具有显著优势。本研究通过使用3D打印技术将神经保护性硫酸镁颗粒掺入聚（L-丙交酯-共-ε-己内酯）（PLCL）基质中，引入了一种新型的镁洗脱支架。引入了一种新型的硫酸镁颗粒/镁离子联合机械增强机制。随后，通过体外氧糖剥夺/复氧损伤的神经元细胞以及通过短暂性大脑中动脉闭塞大鼠模型在体内模拟人脑缺血/再灌注损伤，验证了支架的神经保护效果。镁的阶段性释放应提供与急性缺血性中风治疗窗口相匹配的序贯神经保护。本研究标志着可生物降解神经保护脑支架的首次开发，并提出了一种减轻脑缺血再灌注损伤的有效策略。
