Anghileri L J, Heidbreder M, Weiler G, Dermietzel R
Tumori. 1977 Jan-Feb;63(1):7-14. doi: 10.1177/030089167706300102.
In a series of experiments the prolonged feeding of rats with thioacetamide and 4-dimethylaminoazobenzene provoked an increase in mitochondrial calcium. It seems likely that this continuous mitochondrial overloading with Ca2+ is related to metabolic and functional changes of the liver cell leading to a neoplastic transformation. The drastic changes in cell membrane permeability of cholangiocarcinoma tumor cells, reflected by an increased concentration of extracellular cations (calcium and sodium), while the intracellular cations tended to decrease, indicate that the mitochondrial function of specification of cell membrane characteristics is possibly impaired by that calcification.
在一系列实验中，用硫代乙酰胺和4-二甲基氨基偶氮苯长期喂养大鼠，会导致线粒体钙含量增加。这种持续的线粒体钙超载似乎与肝细胞的代谢和功能变化有关，进而导致肿瘤转化。胆管癌细胞细胞膜通透性的剧烈变化表现为细胞外阳离子（钙和钠）浓度增加，而细胞内阳离子趋于减少，这表明钙化可能损害了决定细胞膜特性的线粒体功能。
