Diexer Sophie, Frost Jonas, Ahnert Peter, Baernighausen Till W, Brenner Hermann, Fricke Julia, Gabrysch Sabine, Greiser Karin Halina, Harth Volker, Heise Jana-Kristin, Kaaks Rudolf, Karch André, Keil Thomas, Klee Bianca, Klett-Tammen Carolina J, Krist Lilian, Lampl Benedikt M J, Leitzmann Michael F, Lieb Wolfgang, Meinke-Franze Claudia, Michels Karin B, Velásquez Ilais Moreno, Obi Nadia, Peters Annette, Pfrommer Laura R, Pischon Tobias, Purschke Oliver, Rübsamen Nicole, Schikowski Tamara, Schmidt Börge, Thierry Sigrid, Völzke Henry, Wright Marvin N, Zeeb Hajo, Mikolajczyk Rafael
Institute for Medical Epidemiology, Biometrics and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Magdeburger Str. 8, 06112, Halle (Saale), Germany.
Institute for Medical Informatics, Statistics and Epidemiology, Universität Leipzig, Leipzig, Germany.
Sci Rep. 2025 Jul 16;15(1):25830. doi: 10.1038/s41598-025-07894-7.
Post COVID-19 condition (PCC) is a substantial burden for patients, society, and the healthcare system. Participants of the German National Cohort (NAKO) were asked in an online survey about their self-perceived health, symptoms related to PCC, and infection status. PCC was defined as reporting symptoms for the time window 4-12 months after infection. Of 110,375 respondents (73% response), 86,833 were included in this analysis. Of these, 44,451 (51%) did not report a SARS-CoV-2 infection (no infection), 26,726 (31%) reported an infection but no symptoms 4-12 months after infection (infection/no PCC), and 15,656 (18%) reported an infection and symptoms (PCC). The median number of current symptoms at the time of the survey was two for the "no infection" and the "infection/no PCC" group, and five for the "PCC" group. Participants with PCC had a substantially higher probability of having worse self-perceived health (OR 1.84, 95% CI [1.75; 1.93] compared to the "no infection" group, adjusting for sex, age, education and chronic diseases with elevated risk for developing PCC. After adjusting for the number of current symptoms related to PCC, this difference disappeared, suggesting that the symptoms collected explain the impairment of self-perceived health in the PCC group.
新冠后状况（PCC）给患者、社会和医疗系统带来了沉重负担。德国国民队列研究（NAKO）的参与者在一项在线调查中被问及他们自我感知的健康状况、与PCC相关的症状以及感染状况。PCC被定义为在感染后4至12个月的时间段内报告有症状。在110375名受访者中（回复率73%），86833人被纳入本分析。其中，44451人（51%）未报告感染过严重急性呼吸综合征冠状病毒2（SARS-CoV-2）（未感染），26726人（31%）报告感染过但在感染后4至12个月没有症状（感染/无PCC），15656人（18%）报告感染且有症状（PCC）。在调查时，“未感染”组和“感染/无PCC”组当前症状的中位数为2个，“PCC”组为5个。与“未感染”组相比，患有PCC的参与者自我感知健康状况较差的可能性显著更高（比值比1.84，95%置信区间[1.75；1.93]），在对性别、年龄、教育程度和患PCC风险升高的慢性病进行调整后。在对与PCC相关的当前症状数量进行调整后
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