Kennedy Allison, Gray Clare, Sheridan Nicole, Dunn Leigh, Stewart Jayme, Drouin Stéphanie, Elliott Hannah, Adeponle Ademola, Barrowman Nicholas, Sucha Ewa, Cappelli Mario, Norris Mark L, Jabbour Mona, Cloutier Paula
Children's Hospital of Eastern Ontario (CHEO), 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.
CHEO Research Institute, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.
Child Adolesc Psychiatry Ment Health. 2025 Jul 16;19(1):78. doi: 10.1186/s13034-025-00941-1.
OBJECTIVES: Suicide is the second leading cause of mortality among Canadian youth. As wait times for mental health (MH) support have increased, adolescents with mild-to-moderate suicidal ideation (SI) are waiting longer for support compared to those with more acute SI. Building Resilience and Attachment in Vulnerable Adolescents (BRAVA) is a 6-week virtual group intervention designed to provide support to adolescents with mild to moderate SI and their caregivers. We conducted a randomized controlled trial to assess the efficacy of BRAVA in reducing symptoms of SI, depression, and anxiety in adolescents, and improving life stress in caregivers. DESIGN/METHODS: Outcome measures were administered to both groups [BRAVA, Enhanced Treatment-as-Usual (ETU)] at intake and exit, and at 3-month follow-up (BRAVA only) for SI (primary outcome), anxiety and depression (adolescent), perceived stress (youth and caregiver), attachment and family functioning (caregiver). SI was measured using Suicidal Ideation Questionnaire Junior. Intention to treat (ITT) analysis was performed for youth and caregiver cohorts. RESULTS: Ninety-nine eligible youth presenting with mild-to-moderate SI and their caregivers were recruited from hospital and community MH services. Families were randomized to BRAVA (n = 50) or ETU (n = 49). Adolescents were on average 14.6 years old, mostly female (64%), and of European racial heritage (44%). In ITT analysis, both BRAVA and ETU groups improved in youth SI from intake to exit, with no statistically significant differences between groups at exit. Sensitivity analysis without multiple imputations demonstrated a significant difference in SI scores at exit between the groups, where improvements in the BRAVA group were maintained at 3-month follow-up. Significant differences between groups on youth perceived stress, and depression and anxiety scores were also observed in BRAVA participants at post-treatment compared to the ETU control group. No statistically significant differences were observed for any caregiver outcomes measured except a trend for improved perceived caregiver stress in the BRAVA group post-treatment. CONCLUSIONS: BRAVA was associated with significantly greater improvements in anxiety/depression and adolescent perceived stress compared to ETU. Although the intervention did not result in significant caregiver reported improvements, group cohesion and treatment satisfaction were high for both youth and caregivers. CLINICAL TRIAL REGISTRATION: BRAVA: Building Resilience and Attachment in Vulnerable Adolescents (BRAVA); https://clinicaltrials.gov/ : NCT04751968.
目的:自杀是加拿大青少年中第二大死亡原因。随着心理健康(MH)支持的等待时间增加,与有更急性自杀意念(SI)的青少年相比,有轻度至中度自杀意念的青少年等待支持的时间更长。在脆弱青少年中建立复原力和依恋关系(BRAVA)是一项为期6周的虚拟团体干预措施,旨在为有轻度至中度自杀意念的青少年及其照顾者提供支持。我们进行了一项随机对照试验,以评估BRAVA在减轻青少年自杀意念、抑郁和焦虑症状以及改善照顾者生活压力方面的效果。 设计/方法:在入组和退出时以及3个月随访时(仅针对BRAVA组)对两组[BRAVA组、强化常规治疗(ETU)组]进行结局测量,测量指标包括自杀意念(主要结局)、焦虑和抑郁(青少年)、感知压力(青少年和照顾者)、依恋和家庭功能(照顾者)。使用青少年自杀意念问卷测量自杀意念。对青少年和照顾者队列进行意向性分析(ITT)。 结果:从医院和社区心理健康服务机构招募了99名有轻度至中度自杀意念的符合条件的青少年及其照顾者。家庭被随机分为BRAVA组(n = 50)或ETU组(n = 49)。青少年平均年龄为14.6岁,大多数为女性(64%),欧洲种族血统占44%。在意向性分析中,BRAVA组和ETU组从入组到退出时青少年自杀意念均有所改善,退出时两组之间无统计学显著差异。未进行多次插补的敏感性分析显示,两组退出时自杀意念得分存在显著差异,BRAVA组的改善在3个月随访时得以维持。与ETU对照组相比,BRAVA参与者在治疗后青少年感知压力、抑郁和焦虑得分方面也存在组间显著差异。除了BRAVA组治疗后照顾者感知压力有改善趋势外,在测量的任何照顾者结局方面均未观察到统计学显著差异。 结论:与ETU相比,BRAVA在焦虑/抑郁和青少年感知压力方面有显著更大的改善。尽管该干预措施并未使照顾者报告有显著改善,但青少年和照顾者的团体凝聚力和治疗满意度都很高。 临床试验注册:BRAVA:在脆弱青少年中建立复原力和依恋关系(BRAVA);https://clinicaltrials.gov/ :NCT04751968 。
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