Gong Le-Lan, Zhou He-Jiang, Zhao Quan-Ming, Xu Ning, Huang Feng-Chang, Su Ling-Yan, Li Wen-Liang
The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
College of Food Science and Technology, Yunnan Agricultural University, Kunming, China.
Immun Inflamm Dis. 2025 Jul;13(7):e70213. doi: 10.1002/iid3.70213.
The nucleotide-binding and oligomerization domain-like receptors (NLRs) are pattern recognition receptors. Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3), a member of the NLRs family, can form a protein complex with caspase-1, apoptosis-associated speck-like protein and caspase recruitment domain. And its assembly and activation cause inflammatory reaction and are closely related to the effects of antitumor immunity. The activation of NLRP3 inflammasome can induce polarization, hyperactivity or pyroptosis of immune cells, releasing interleukin-1β (IL-1β) and interleukin-18, which leads a cascade immunity or inflammatory responses. As an important component of the innate immune system, the NLRP3 inflammasome plays vital roles inflammatory diseases and tumors. In this review, we attempt to summarize the recent findings about the role of NLRP3 in the pathogenesis of tumors and inflammatory diseases such as diabetes, Alzheimer disease, and atherosclerosis.
核苷酸结合寡聚化结构域样受体（NLRs）是模式识别受体。核苷酸结合寡聚化结构域样受体家族含pyrin结构域3（NLRP3）是NLRs家族的成员之一，可与半胱天冬酶-1、凋亡相关斑点样蛋白和半胱天冬酶募集结构域形成蛋白复合物。其组装和激活会引发炎症反应，且与抗肿瘤免疫效应密切相关。NLRP3炎性小体的激活可诱导免疫细胞极化、活性增强或发生焦亡，释放白细胞介素-1β（IL-1β）和白细胞介素-18，从而引发级联免疫或炎症反应。作为固有免疫系统的重要组成部分，NLRP3炎性小体在炎症性疾病和肿瘤中发挥着至关重要的作用。在本综述中，我们试图总结NLRP3在肿瘤发病机制以及糖尿病、阿尔茨海默病和动脉粥样硬化等炎症性疾病中作用的最新研究发现。
