Yi He, Li Ruijue, Li Cuixian
Department of Comprehensive Plastic Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Plastic Surgery Hospital, Beijing, China.
Clinical Specialty, Zhengzhou University School of Medicine, Zhengzhou, China.
Int J Low Extrem Wounds. 2025 Jul 17:15347346251359067. doi: 10.1177/15347346251359067.
AimsBurn injuries cause significant mortality, morbidity, and financial and psychological burdens for patients and families. Platelet-rich plasma (PRP) has shown some benefits in burn wound healing, but its efficacy is unproven. This meta-analysis aimed to evaluate PRP's effects on burn wounds.MethodA comprehensive search of Scopus, PubMed, Web of Science, and Cochrane Library was conducted until January 22, 2025, for randomized controlled trials (RCTs) on PRP's effect on burn wounds. The mean difference (MD), standardized MD (SMD), or odds ratio (OR) of the studies was calculated.ResultsNine RCTs with 413 participants were included. PRP significantly reduced wound healing time (MD: -6.68 days, 95% CI (-10.96, -2.39)), wound infection incidence (OR: 0.18, 95% CI (0.04, 0.88)), and dressing change frequency (MD: -14.50 times, 95% CI (-16.45, -12.55)). There was a significant increase in the healed area percentage in the intervention group (MD: 6.82%, 95% CI (2.58, 11.06)). However, there was no significant difference between the intervention and control groups in pain score or graft take percentage.ConclusionsThis review shows that PRP enhances wound healing and reduces adverse events like wound infection in burn patients. Future studies should further explore PRP's effects to support its broader clinical use.
目的
烧伤会给患者及其家庭带来巨大的死亡率、发病率以及经济和心理负担。富血小板血浆（PRP）在烧伤创面愈合方面已显示出一些益处，但其疗效尚未得到证实。本荟萃分析旨在评估PRP对烧伤创面的影响。
方法
对Scopus、PubMed、Web of Science和Cochrane图书馆进行全面检索，直至2025年1月22日，以查找关于PRP对烧伤创面影响的随机对照试验（RCT）。计算各研究的平均差（MD）、标准化平均差（SMD）或比值比（OR）。
结果
纳入了9项随机对照试验，共413名参与者。PRP显著缩短了伤口愈合时间（MD：-6.68天，95%置信区间（-10.96，-2.39））、伤口感染发生率（OR：0.18，95%置信区间（0.04，0.88））和换药频率（MD：-14.50次，95%置信区间（-16.45，-12.55））。干预组的愈合面积百分比显著增加（MD：6.82%，95%置信区间（2.58，11.06））。然而，干预组和对照组在疼痛评分或植皮成活率方面没有显著差异。
结论
本综述表明，PRP可促进烧伤患者的伤口愈合并减少诸如伤口感染等不良事件。未来的研究应进一步探索PRP的作用，以支持其更广泛的临床应用。
