Thomazi Rafael, Dos Santos Carlos Alberto, Jacinto Alessandro Ferrari
Universidade Estadual Paulista, Botucatu SP Brazil.
Centro Universitário de Adamantina, Departamento de Medicina, Adamantina SP, Brazil.
Dement Neuropsychol. 2025 Jul 11;19:e20240228. doi: 10.1590/1980-5764-DN-2024-0228. eCollection 2025.
Prescription of psychotropic drugs and potentially inappropriate medications (PIMs) for older adults is a common condition. Assessing the factors associated with this prescription is essential especially within the hospital setting, requiring the implementation of strategies for promoting rational use of medications in this age group.
To evaluate factors associated with the use of psychotropic drugs in hospitalized older adults.
Cross-sectional study, conducted at Hospital das Clínicas de Botucatu, Brazil. Patients were divided into clinical patients taking or not taking psychotropic drugs and surgical patients taking or not taking psychotropic drugs. Multivariate analysis was performed, adopting "use or non-use of psychotropic drugs" and "having geriatrician as prescriber before hospitalization or otherwise", as dependent variables.
Of the 385 participants, 60% practiced polypharmacy and 55% were in use of PIM. Clinical patients using psychotropic drugs took more PIM (p<0.001) and more medications (p=0.002) than non-users. For the total sample, PIM use was associated with a 4.53 times greater chance of taking psychotropic drugs, and each additional medication used was associated with a 1.15 times greater chance of taking psychotropic drugs. Being accompanied by a geriatrician before hospital admission was associated with a 4.0 times greater chance of no PIM being prescribed.
PIM use and polypharmacy were associated with an increased chance of taking psychotropic drugs. Being accompanied by a geriatrician before hospitalization was associated with a lower chance of PIM use.
为老年人开具精神药物和潜在不适当药物(PIMs)是一种常见情况。评估与这种处方相关的因素至关重要,尤其是在医院环境中,这需要实施促进该年龄组合理用药的策略。
评估住院老年人使用精神药物的相关因素。
在巴西博图卡图临床医院进行横断面研究。患者分为服用或未服用精神药物的临床患者以及服用或未服用精神药物的外科患者。采用“使用或不使用精神药物”以及“住院前是否有老年病医生作为开处方者”作为因变量进行多变量分析。
在385名参与者中,60%存在多重用药情况,55%使用PIM。使用精神药物的临床患者比未使用者服用更多的PIM(p<0.001)和更多药物(p=0.002)。对于总样本,使用PIM与服用精神药物的可能性高4.53倍相关,每多使用一种药物与服用精神药物的可能性高1.15倍相关。入院前有老年病医生陪同与未开具PIM的可能性高4.0倍相关。
使用PIM和多重用药与服用精神药物的可能性增加相关。住院前有老年病医生陪同与使用PIM的可能性降低相关。