Gregory Nicholas S, Girard Tyler E, Ram Akila, Casey Austen B, Malenka Robert C, Tawfik Vivianne L, Heifets Boris D
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
bioRxiv. 2025 Jul 7:2025.07.06.663398. doi: 10.1101/2025.07.06.663398.
The psychedelic psilocybin may have lasting therapeutic effects for patients with chronic pain syndromes. Some clinical and preclinical data suggest these putative benefits derive from direct analgesic effects. However, this possibility has not been comprehensively tested in preclinical models. Here, we show that psilocybin is not analgesic over a range of doses across multiple pain assays and models of acute and chronic inflammatory, neuropathic, or musculoskeletal pain in mice.
迷幻剂裸盖菇素可能对慢性疼痛综合征患者具有持久的治疗效果。一些临床和临床前数据表明，这些假定的益处源于直接的镇痛作用。然而，这种可能性尚未在临床前模型中得到全面测试。在此，我们表明，在多种疼痛测定以及小鼠急性和慢性炎症性、神经性或肌肉骨骼疼痛模型中，裸盖菇素在一系列剂量范围内均无镇痛作用。
