Maki J, Yanagisawa T
J Helminthol. 1985 Sep;59(3):211-6. doi: 10.1017/s0022149x00007963.
The anthelmintic effects of anti-tapeworm drugs, bithionol, paromomycin sulphate, flubendazole and mebendazole on immature and mature Hymenolepis nana in mice were compared. Immature worms were not affected by paromomycin sulphate or flubendazole administered for 12 consecutive days (days one to 12 after infection) at 100 mg/kg/day but 48% and 100% of H. nana were eliminated from mice by bithionol and mebendazole respectively, at the same dosage regimen. Bithionol, paromomycin sulphate, flubendazole and mebendazole given at 100 mg/kg/day for five consecutive days (days 12 to 16 after infection) eliminated 32%, 29%, 36% and 100% of mature worms respectively. 10 and 20 mg of mebendazole/kg/day for five consecutive days (days 12 to 16 after infection) had little effect on mature worms whereas 50 and 100 mg/kg/day for the same period eliminated 99% and 100% of mature worms, respectively. ED50 of mebendazole in the elimination of mature H. nana was 14 or 15 mg/kg/day for five days from the reduction in dry weight or in number of worms recovered respectively. The effects of mebendazole given 2 to 4 days, 8 to 10 days or 13 to 15 days after infection at 100 mg/kg/day were compared. Very low, if any, activity of the drug given 2 to 4 days after infection was seen, whereas the drug given 8 to 10 days or 13 to 15 days after infection eliminated 84% and 86% of H. nana respectively.
比较了抗绦虫药物硫双二氯酚、硫酸巴龙霉素、氟苯达唑和甲苯达唑对小鼠体内未成熟和成熟微小膜壳绦虫的驱虫效果。连续12天（感染后第1天至第12天）以100mg/kg/天的剂量给予硫酸巴龙霉素或氟苯达唑，对未成熟虫体无影响，但在相同给药方案下，硫双二氯酚和甲苯达唑分别使48%和100%的微小膜壳绦虫从小鼠体内被清除。连续5天（感染后第12天至第16天）以100mg/kg/天的剂量给予硫双二氯酚、硫酸巴龙霉素、氟苯达唑和甲苯达唑，分别清除了32%、29%、36%和100%的成熟虫体。连续5天（感染后第12天至第16天）以10mg/kg/天和20mg/kg/天的剂量给予甲苯达唑，对成熟虫体影响不大，而同期以50mg/kg/天和100mg/kg/天的剂量给予甲苯达唑，则分别清除了99%和100%的成熟虫体。根据虫体干重减少或回收虫体数量减少情况，甲苯达唑清除成熟微小膜壳绦虫的半数有效剂量（ED50）为连续5天14或15mg/kg/天。比较了感染后2至4天、8至10天或13至15天以100mg/kg/天的剂量给予甲苯达唑的效果。感染后2至4天给予该药物，即使有活性也非常低，而感染后8至10天或13至15天给予该药物，分别清除了84%和86%的微小膜壳绦虫。
