Wang Yiyang, Liu Xiao, Qi Li, Qin Jing, Tang Xiaoqing, Wu Xiaohua, Sun Shanquan, Xiang Hui
Chongqing Medical University-University of Leicester Joint Institute, Chongqing Medical University Chongqing 400016, China.
Jiangbei District Center for Disease Control and Prevention Chongqing 400020, China.
Am J Transl Res. 2025 Jun 15;17(6):4493-4505. doi: 10.62347/ADBC6620. eCollection 2025.
Monkeypox (Mpox) was declared a public health emergency by World Health Organization (WHO) in 2024. This study aimed to identify subpopulations of men who have sex with men (MSM) in Chongqing, China, who may perceive themselves to be at risk of Mpox infection.
In September 2023, a cross-sectional online survey was conducted with the support of non-governmental organizations (NGOs). A total of 760 MSM were recruited to assess their socio-demographic characteristics, Mpox-related knowledge and awareness, risk perceptions, behavioral risk factors, and willingness to receive Mpox vaccination.
Among the participants, 219 (28.8%) were HIV-positive. Significant heterogeneity was observed across HIV statuses in terms of geographic origin, household registration, education level, income, sexual role, and other factors. After adjusting for age, a multivariable linear regression model revealed that Mpox risk perception was positively associated with higher levels of Mpox knowledge (β = -0.64, 95% confidence intervals (CI): -1.01 to -0.27, P < 0.001), experiences of stigma or discrimination (β = -0.20, 95% CI: -0.31 to -0.08, P < 0.001), and willingness to be vaccinated (β = 0.76, 95% CI: 0.64 to 0.88, P < 0.001). It was negatively associated with lower educational attainment and fewer high-risk sexual behaviors (β = 0.30, 95% CI: 0.12-0.48, P = 0.001).
HIV-positive MSM, particularly those of lower socioeconomic status and educational attainment, tend to perceive themselves at lower risk of Mpox infection. Future interventions targeting MSM should focus on enhancing disease knowledge, fostering inclusive attitudes, and offering psychological support. Broader societal efforts to promote tolerance and reduce stigma are also essential.
2024年，世界卫生组织（WHO）宣布猴痘为突发公共卫生事件。本研究旨在识别中国重庆男男性行为者（MSM）中可能认为自己有感染猴痘风险的亚群体。
2023年9月，在非政府组织（NGO）的支持下开展了一项横断面在线调查。共招募了760名男男性行为者，以评估他们的社会人口学特征、与猴痘相关的知识和意识、风险认知、行为风险因素以及接种猴痘疫苗的意愿。
在参与者中，219人（28.8%）为HIV阳性。在地理来源、户籍、教育水平、收入、性角色及其他因素方面，不同HIV状态间存在显著异质性。调整年龄后，多变量线性回归模型显示，猴痘风险认知与更高水平的猴痘知识呈正相关（β = -0.64，95%置信区间（CI）：-1.01至-0.27，P < 0.001），与遭受耻辱或歧视的经历呈正相关（β = -0.20，95%CI：-0.31至-0.08，P < 0.001），与接种意愿呈正相关（β = 0.76，95%CI：0.64至0.88，P < 0.001）。它与较低的教育程度和较少的高危性行为呈负相关（β = 0.30，95%CI：0.12 - 0.48，P = 0.001）。
HIV阳性的男男性行为者，尤其是社会经济地位较低和教育程度较低的人群，往往认为自己感染猴痘的风险较低。未来针对男男性行为者的干预措施应侧重于增强疾病知识、培养包容态度并提供心理支持。更广泛的社会努力以促进宽容和减少耻辱感也至关重要。
