Teng Qibei, Yang Qianqian, Tao Zhizhi, Huang Jinwen, Zhang Cheng, Shao Fangfei, Pan Wenjue, Zhao Xiujie, Xiao Haowen
Department of Hematology and Cell Therapy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Front Med (Lausanne). 2025 Jul 2;12:1608828. doi: 10.3389/fmed.2025.1608828. eCollection 2025.
Invasive mucormycosis contributes to a high mortality rate in patients with hematological malignancies. When it disseminates to multiple organs, especially to the brain, the prognosis is extremely poor. The traditional antifungal strategies including surgery have less efficacy in patients with hematological malignancies. Here, we describe a case report of a 62-year-old man with refractory lymphoma who developed mucormycosis caused by after chemotherapy, which disseminated extensively to the lungs, diaphragm, brain and spleen. He was successfully treated with antifungal agents combined with PD-1 inhibitor, which may simultaneously exhibit efficacy in treatment of lymphoma and mucormycosis. The patient's lymphoma and mucormycosis were well controlled; ultimately, autologous hematopoietic stem cell transplantation was successfully performed, and the patient achieved long-term survival.
侵袭性毛霉病导致血液系统恶性肿瘤患者死亡率很高。当它播散至多个器官，尤其是脑部时，预后极差。包括手术在内的传统抗真菌策略对血液系统恶性肿瘤患者疗效较差。在此，我们报告一例62岁难治性淋巴瘤男性患者，化疗后发生由 引起的毛霉病，广泛播散至肺、膈肌、脑和脾脏。他接受抗真菌药物联合PD-1抑制剂治疗成功，该联合治疗可能对淋巴瘤和毛霉病同时具有疗效。患者的淋巴瘤和毛霉病得到良好控制；最终成功进行了自体造血干细胞移植，患者实现长期生存。 （注：原文中“caused by after chemotherapy”部分有缺失信息）
