联合抗真菌治疗与免疫刺激用于治疗由小孢子根霉引起的难治性皮肤和腹膜毛霉病。
Combined antifungal therapy with immunostimulation for refractory cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus.
作者信息
Mhenni Rania, Dellière Sarah, Maaouia Chiheb Ben, Hamane Samia, Deniau Benjamin, Mahévas Thibault, Chaussard Maité, Coutrot Maxime, Guillemet Lucie, Cupaciu Alexandru, Pharaboz Alexandre, Walter Thais, Boutin Louis, Benyamina Mourad, Corte Hélène, Delale Charles, Chaouat Marc, Guihot Amélie, Lanternier Fanny, Alanio Alexandre, Dépret François, Serris Alexandra, Dudoignon Emmanuel
机构信息
Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France.
University of Paris Cité, Paris, France; Department of mycology and parasitology, Paris.
出版信息
Diagn Microbiol Infect Dis. 2025 Mar;111(3):116653. doi: 10.1016/j.diagmicrobio.2024.116653. Epub 2024 Dec 14.
Mucormycosis is a fungal infection typically affecting immunocompromised patients. Here, we report a severe case of invasive cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus, successfully treated with a combination of antifungal therapy, PD-1 inhibitor, and interferon-gamma. We highlight the importance of personalized immunotherapy in refractory cases of invasive mucormycosis.
毛霉病是一种通常影响免疫功能低下患者的真菌感染。在此，我们报告一例由微小根霉引起的侵袭性皮肤和腹膜毛霉病重症病例，通过抗真菌治疗、PD-1抑制剂和干扰素-γ联合治疗成功治愈。我们强调了个性化免疫疗法在侵袭性毛霉病难治性病例中的重要性。
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