氨曲南、替莫西林、庆大霉素和妥布霉素对人粪便的结合及抗菌作用。
Binding to and antibacterial effect of aztreonam, temocillin, gentamicin and tobramycin on human faeces.
作者信息
Hazenberg M P, Pennock-Schröder A M, van de Merwe J P
出版信息
J Hyg (Lond). 1985 Oct;95(2):255-63. doi: 10.1017/s0022172400062689.
Abstract
Aztreonam, temocillin, gentamicin and tobramycin were studied for their effect on the human faecal flora in vitro and for their usefulness for selective decontamination (SD) of the gastrointestinal tract. The sensitivities of the obligately anaerobic flora and the Gram-negative facultatively anaerobic bacteria were determined and the ratio was expressed as SD factor. The high SD factor of the flora from most subjects for aztreonam and tobramycin indicates that the drugs are useful for SD in contrast to temocillin and gentamicin. Binding to and subsequent release of tobramycin from faeces are presumed to facilitate the maintenance of adequate concentrations in the intestine despite the discontinuous intake.
摘要
研究了氨曲南、替莫西林、庆大霉素和妥布霉素对人体粪便菌群的体外作用及其在胃肠道选择性去污（SD）中的效用。测定了专性厌氧菌和革兰氏阴性兼性厌氧菌的敏感性，并将该比值表示为SD因子。大多数受试者粪便菌群对氨曲南和妥布霉素的高SD因子表明，与替莫西林和庆大霉素相比，这些药物对SD有用。据推测，妥布霉素与粪便的结合及随后从粪便中的释放有助于在不连续给药的情况下维持肠道中的足够浓度。
相似文献
1
Binding to and antibacterial effect of aztreonam, temocillin, gentamicin and tobramycin on human faeces.氨曲南、替莫西林、庆大霉素和妥布霉素对人粪便的结合及抗菌作用。
J Hyg (Lond). 1985 Oct;95(2):255-63. doi: 10.1017/s0022172400062689.
2
Oral administration of antibiotics and intestinal flora associated endotoxin in mice.小鼠口服抗生素与肠道菌群相关内毒素
Scand J Infect Dis. 1986;18(1):55-63. doi: 10.3109/00365548609032307.
3
Temocillin. In vitro antibacterial activity.
Drugs. 1985;29 Suppl 5:49-56. doi: 10.2165/00003495-198500295-00011.
4
Biological inactivation by faeces of antimicrobial drugs applicable in selective decontamination of the digestive tract.适用于消化道选择性去污的抗菌药物被粪便生物灭活。
J Antimicrob Chemother. 1984 Dec;14(6):605-12. doi: 10.1093/jac/14.6.605.
5
Selective decontamination of the digestive tract with oral aztreonam and temocillin.口服氨曲南和替莫西林对消化道进行选择性去污。
Rev Infect Dis. 1985 Nov-Dec;7 Suppl 4:S628-34. doi: 10.1093/clinids/7.supplement_4.s628.
6
Beta-lactamase stability and in vitro activity of aztreonam, with a comparison to 9 other beta-lactam antibiotics and gentamicin.氨曲南的β-内酰胺酶稳定性及体外活性，并与其他9种β-内酰胺类抗生素和庆大霉素进行比较。
Chemotherapy. 1986;32(4):329-35. doi: 10.1159/000238431.
7
Antibacterial activity of ticarcillin, tobramycin and gentamicin alone and in combination against Pseudomonas aeruginosa in vitro.替卡西林、妥布霉素和庆大霉素单独及联合应用对铜绿假单胞菌的体外抗菌活性。
Chemotherapy. 1977;23(5):314-23. doi: 10.1159/000222001.
8
Aztreonam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.氨曲南。对其抗菌活性、药代动力学特性及治疗用途的综述。
Drugs. 1986 Feb;31(2):96-130. doi: 10.2165/00003495-198631020-00002.
9
Influence of temocillin on human bowel flora.替莫西林对人体肠道菌群的影响。
Drugs. 1985;29 Suppl 5:43-8. doi: 10.2165/00003495-198500295-00010.
10
In vitro activity of tobramycin and gentamicin against Enterobacteriaceae and gentamicin-resistant, carbenicillin-resistant Pseudomonas aeruginosa.妥布霉素和庆大霉素对肠杆菌科细菌以及耐庆大霉素、耐羧苄西林铜绿假单胞菌的体外活性。
Curr Ther Res Clin Exp. 1975 May;17(5):488-96.
引用本文的文献
1
Norfloxacin binds to human fecal material.诺氟沙星与人类粪便物质结合。
Antimicrob Agents Chemother. 1988 Dec;32(12):1869-74. doi: 10.1128/AAC.32.12.1869.
2
The non-enzymatic inactivation of thirteen beta-lactam antibiotics in human faeces.13种β-内酰胺类抗生素在人粪便中的非酶失活作用
Infection. 1992 Nov-Dec;20(6):355-9. doi: 10.1007/BF01710684.
本文引用的文献
1
Bacteriological aspects of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients.作为粒细胞减少症患者感染预防方法的消化道选择性去污的细菌学方面
Antimicrob Agents Chemother. 1981 May;19(5):813-20. doi: 10.1128/AAC.19.5.813.
2
Selective antimicrobial modulation of human microbial flora: infection prevention in patients with decreased host defense mechanisms by selective elimination of potentially pathogenic bacteria.人类微生物群的选择性抗菌调节：通过选择性清除潜在致病细菌预防宿主防御机制降低患者的感染
J Infect Dis. 1981 May;143(5):644-54. doi: 10.1093/infdis/143.5.644.
3
Effects of the human intestinal flora on germ-free mice.人类肠道菌群对无菌小鼠的影响。
J Appl Bacteriol. 1981 Feb;50(1):95-106. doi: 10.1111/j.1365-2672.1981.tb00874.x.
4
Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract.通过消化道选择性去污对粒细胞缺乏症患者进行感染预防。
Eur J Cancer (1965). 1980 Jun;16(6):859-69. doi: 10.1016/0014-2964(80)90140-1.
5
BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans.BRL 17421是一种新型β-内酰胺抗生素，对β-内酰胺酶具有高度抗性，在人体内可产生高且持久的血清浓度。
Antimicrob Agents Chemother. 1981 Jul;20(1):38-46. doi: 10.1128/AAC.20.1.38.
6
Antimicrobial prophylaxis in acute leukaemia: prospective randomized study comparing two methods of selective decontamination.
Klin Wochenschr. 1983 Jul 15;61(14):691-8. doi: 10.1007/BF01487614.
7
Selective antimicrobial modulation of the intestinal flora of patients with acute nonlymphocytic leukemia: a double-blind, placebo-controlled study.急性非淋巴细胞白血病患者肠道菌群的选择性抗菌调节：一项双盲、安慰剂对照研究。
J Infect Dis. 1983 Apr;147(4):615-23. doi: 10.1093/infdis/147.4.615.
8
Antimicrobial prophylaxis against infection in neutropenic patients.中性粒细胞减少患者感染的抗菌预防。
J Infect Dis. 1983 Apr;147(4):611-4. doi: 10.1093/infdis/147.4.611.
9
The screening of four aminoglycosides in the selective decontamination of the digestive tract in mice.小鼠消化道选择性去污中四种氨基糖苷类药物的筛选。
Infection. 1982 Jan;10(1):35-40. doi: 10.1007/BF01640836.
10
Oral bioavailability of the monobactam aztreonam (SQ 26,776) in healthy subjects.健康受试者中单环β-内酰胺类氨曲南（SQ 26,776）的口服生物利用度。
Antimicrob Agents Chemother. 1983 Apr;23(4):548-50. doi: 10.1128/AAC.23.4.548.
Zotero 插件