一例通过宏基因组下一代测序诊断的小儿猫抓病，并发脑膜炎。
A pediatric case of cat scratch disease, complicated by meningitis, diagnosed by metagenomic next-generation sequencing.
作者信息
Jin Li, Wen Yang, Li Yiyuan
机构信息
Department of Pediatric Infectious Diseases Nursing Unit, West China Second Hospital, Sichuan University, Sichuan, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (SichuanUniversity), Ministry of Education, Chengdu, Sichuan, China.
出版信息
Turk J Pediatr. 2025 Jul 6;67(3):428-432. doi: 10.24953/turkjpediatr.2025.5960.
BACKGROUND
Cat scratch disease (CSD) presents with diverse symptoms; however, meningitis as a complication is rare, and effective treatment strategies remain underexplored.
CASE PRESENTATION
An 11-year-old girl presented with a prolonged fever of unknown origin, mild cough, and headache. Metagenomic next-generation sequencing (mNGS) identified Bartonella henselae in the bloodstream, and cerebrospinal fluid analysis confirmed meningitis. The patient was diagnosed with CSD complicated by meningitis and demonstrated a successful recovery following treatment with doxycycline, rifampicin, and prednisone.
CONCLUSIONS
In CSD patients presenting with headaches and persistent fever, the possibility of meningitis should be considered. mNGS is a valuable diagnostic tool for CSD, especially in cases of fever of unknown origin. The combination of doxycycline, rifampicin, and prednisone proved effective in managing CSD with meningitis.
背景
猫抓病（CSD）症状多样；然而，作为并发症的脑膜炎较为罕见，有效的治疗策略仍未得到充分探索。
病例报告
一名11岁女孩出现不明原因的长期发热、轻度咳嗽和头痛。宏基因组下一代测序（mNGS）在血液中检测到汉赛巴尔通体，脑脊液分析确诊为脑膜炎。该患者被诊断为CSD并发脑膜炎，经强力霉素、利福平及泼尼松治疗后康复。
结论
对于出现头痛和持续发热的CSD患者，应考虑脑膜炎的可能性。mNGS是CSD的一种有价值的诊断工具，尤其是在不明原因发热的病例中。强力霉素、利福平及泼尼松联合使用被证明对治疗CSD并发脑膜炎有效。
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