Jakubaszek Michal, Kwiatkowska Brygida, Płaza Mateusz, Maślińska Maria
National Institute of Geriatrics Rheumatology and Rehabilitation in Warsaw, Warszawa, Poland.
Rheumatol Int. 2025 Jul 17;45(8):172. doi: 10.1007/s00296-025-05920-5.
This single-center study aimed to evaluate relationship between the concentration of anti-citrullinated protein antibodies (ACPA) and the degree of synovial perfusion in patients with high disease activity of rheumatoid arthritis (RA). The study enrolled 60 patients diagnosed with RA and group of 20 patients with psoriasis arthritis (PsA). Different laboratory variables were assessed and particularly ACPA (U/ML), disease activity was calculated by DAS 28(ESR) and simplified disease activity score (SDAI). The degree of the synovial membrane vascularization was assessed using power doppler US (PDUS) and additionally vascularity index was measured by PDUS index (INDEX%) in the ROI (region of interest). Correlation between the concentration of ACPA and INDEX% in RA group was confirmed as week positivity indicating that ACPA may be a prognostic factor for vascularization of the synovial membrane in patients with RA.
这项单中心研究旨在评估类风湿关节炎（RA）疾病活动度高的患者中抗瓜氨酸化蛋白抗体（ACPA）浓度与滑膜灌注程度之间的关系。该研究纳入了60例被诊断为RA的患者以及20例银屑病关节炎（PsA）患者组成的对照组。评估了不同的实验室变量，特别是ACPA（U/ML），通过DAS 28（ESR）和简化疾病活动评分（SDAI）计算疾病活动度。使用功率多普勒超声（PDUS）评估滑膜血管化程度，并通过PDUS指数（INDEX%）在感兴趣区域（ROI）测量血管指数。RA组中ACPA浓度与INDEX%之间的相关性被确认为弱阳性，表明ACPA可能是RA患者滑膜血管化的一个预后因素。
