Gedalia A, Person D A, Brewer E J, Giannini E H
J Pediatr. 1985 Dec;107(6):873-6. doi: 10.1016/s0022-3476(85)80178-5.
It has been suggested that hypermobility of the joints may predispose children to the development of arthritis or arthralgia. To determine the normal frequency of hypermobility, 260 normal schoolchildren (5 to 17 years of age) were examined. In addition, 34 patients with juvenile rheumatoid arthritis (JRA) and 32 children with juvenile episodic arthritis/arthralgia (JEA) were tested. Any child who met at least three of the following criteria was considered to have joint hypermobility: (1) passive apposition of the thumbs to the flexor aspect of the forearms; (2) passive hyperextension of the fingers so that they lie parallel with the extensor aspect of the forearms; (3) hyperextension of the elbows greater than 10 degrees; (4) hyperextension of the knees greater than 10 degrees; (5) flexion of the trunk with knees extended so the palms rest on the floor. Thirty-two (12%) of 260 normal schoolchildren and 21 (66%) of 32 with JEA had hypermobility. Further, a significantly higher proportion (23 of 126) of normal girls than normal boys (nine of 134) had hypermobility (chi 2 = 8.0, P less than 0.005). Hypermobility was not common in children with JRA. These findings support the hypothesis that hypermobility may be an important factor in the cause of JEA.
有人提出，关节活动过度可能使儿童易患关节炎或关节痛。为了确定关节活动过度的正常发生率，对260名正常学童（5至17岁）进行了检查。此外，还对34例幼年类风湿关节炎（JRA）患者和32例幼年发作性关节炎/关节痛（JEA）儿童进行了测试。任何满足以下至少三条标准的儿童被认为有关节活动过度：（1）拇指被动贴附于前臂屈侧；（2）手指被动过度伸展，使其与前臂伸侧平行；（3）肘关节过度伸展大于10度；（4）膝关节过度伸展大于10度；（5）膝关节伸直时躯干前屈，使手掌能触及地面。260名正常学童中有32名（占比12%），32名JEA儿童中有21名（占比66%）有关节活动过度。此外，正常女孩中关节活动过度的比例（126名中有23名）显著高于正常男孩（134名中有9名）（卡方检验χ2 = 8.0，P < 0.005）。关节活动过度在JRA儿童中并不常见。这些发现支持了关节活动过度可能是JEA病因中的一个重要因素这一假说。
