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低位前切除综合征（LARS）对直肠癌幸存者生活质量的影响：一项叙述性综述

The impact of Low-Anterior Resection Syndrome (LARS) on the Quality of Life in Rectal Cancer Survivors: a Narrative Review.

作者信息

Stanculea Floris, Ungureanu Claudiu-Octavian, Roca Daniela, Ginghina Octav, Mihailov Raul, Grama Florin, Iordache Niculae

机构信息

"Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania.

General Surgery Department, "Sf. Ioan" Clinical Emergency Hospital, 13 Vitan-Bârzeşti Road, 042122 Bucharest, Romania.

出版信息

Maedica (Bucur). 2025 Mar;20(1):56-64. doi: 10.26574/maedica.2025.20.1.56.

DOI:10.26574/maedica.2025.20.1.56
PMID:40677670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12123494/
Abstract

Low anterior rectal cancer is based on oncological radicality and recurrence rates, which translate to survival. Rectal dysfunction occurred in at least one-quarter of patients. This dysfunction is a myriad of symptoms referred to as low anterior resection syndrome (LARS). In this review, we analyzed the definitions, risk factors and pathophysiological mechanisms of LARS. A better understanding of this syndrome can lead to improved prevention and treatment of LARS.

摘要

低位直肠癌基于肿瘤根治性和复发率，而这两者又与生存率相关。至少四分之一的患者出现直肠功能障碍。这种功能障碍是一系列被称为低位前切除综合征（LARS）的症状。在本综述中，我们分析了LARS的定义、危险因素和病理生理机制。对该综合征的更好理解可改善LARS的预防和治疗。

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本文引用的文献

1
The Diagnosis and Evolution of Patients with LARS Syndrome: A Five-Year Retrospective Study from a Single Surgery Unit.低位前切除综合征患者的诊断与病情进展：来自单一外科单元的五年回顾性研究
Cancers (Basel). 2024 Dec 14;16(24):4175. doi: 10.3390/cancers16244175.
2
Quality of life and functional outcomes after laparoscopic total mesorectal excision (LaTME) and transanal total mesorectal excision (taTME) for rectal cancer. an updated meta-analysis.腹腔镜全直肠系膜切除术（LaTME）和经肛门全直肠系膜切除术（taTME）治疗直肠癌的生活质量和功能结局。一项更新的荟萃分析。
Int J Colorectal Dis. 2024 Aug 9;39(1):129. doi: 10.1007/s00384-024-04703-x.
3
Low Anterior Resection Syndrome and Quality of Life of Patients After Sphincter Preservation Surgery: A Prospective Study.低位前切除术综合征与保肛手术后患者的生活质量：一项前瞻性研究。
Cureus. 2024 May 10;16(5):e60059. doi: 10.7759/cureus.60059. eCollection 2024 May.
4
Low anterior resection syndrome phenotypes-Different symptom profiles for different patients.低位前切除综合征表型-不同患者有不同的症状谱。
Colorectal Dis. 2024 Jun;26(6):1214-1222. doi: 10.1111/codi.17034. Epub 2024 May 27.
5
Meta-analysis: loop ileostomy versus colostomy to prevent complications of anterior resection for rectal cancer.荟萃分析：回肠袢式造口术与结肠造口术预防直肠癌前切除术并发症的比较。
Int J Colorectal Dis. 2024 May 8;39(1):68. doi: 10.1007/s00384-024-04639-2.
6
Incidence of low anterior resection syndrome and its association with the quality of life in patients with lower rectal tumors.低位前切除综合征的发生率及其与低位直肠肿瘤患者生活质量的关系。
Surg Today. 2024 Aug;54(8):857-865. doi: 10.1007/s00595-024-02796-z. Epub 2024 Mar 12.
7
Incidence and risk factors of bowel dysfunction after minimally invasive rectal cancer surgery and discrepancies between the Wexner score and the low anterior resection syndrome (LARS) score.微创直肠癌手术后肠功能障碍的发生率及危险因素，以及 Wexner 评分与低位前切除术综合征（LARS）评分之间的差异。
Surg Today. 2024 Jul;54(7):763-770. doi: 10.1007/s00595-023-02789-4. Epub 2024 Jan 3.
8
Major low anterior resection syndrome has equivalent health-related quality of life implications as having a permanent colostomy.主要低位前切除综合征与永久性结肠造口术具有相当的健康相关生活质量影响。
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