Alkhabaz Anas, Kim Min Young, Pujari Rishita, Zhang Jamie, Ren Yulan, Leung Loh-Shan Bryan, Liao Yaping Joyce
Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, United States.
Oakland University William Beaumont School of Medicine, Rochester, MI, United States.
Front Ophthalmol (Lausanne). 2025 Jul 3;5:1620616. doi: 10.3389/fopht.2025.1620616. eCollection 2025.
The aim of this study was to investigate the risk of age-related macular degeneration (AMD) in association with optic disc drusen (ODD).
This was an observational, cross-sectional study.
Participants were consecutive patients with and without ODD from the neuro-ophthalmology clinic. Ten patients with concomitant ODD-AMD were sub-analyzed.
The two cohorts were identified from a prospectively recruited dataset between July 2022 and June 2024. Patients received formal diagnoses of ODD and AMD after ophthalmic and imaging assessment. A logistic regression model was utilized in calculating AMD risk to account for demographic differences.
A total of 94 patients with ODD (median age: 44 [Q1: 20, Q3: 69], 64% women) and 100 patients without ODD (median age: 60 [Q1: 44, Q3: 69], 48% women) were identified. AMD was observed in 9.6% and 3% of the ODD and non-ODD cohorts, respectively. The risk of AMD was higher in the ODD group (OR = 3.93, 95% CI: 0.89-21.85, = 0.084). Although the association was not statistically significant, a logistic regression model attributed that to the age difference between the two cohorts. Of the 10 patients with ODD-AMD, 70% had a family history of AMD. These patients were all Caucasians and had a median age of 75 years (range: 56-91); 70% were women. Only 30% were smokers. On optic disc imaging, 70% of eyes demonstrated moderate-to-severe ODD.
Patients with ODD might be at a higher risk of AMD compared to patients without ODD, and AMD screening might be warranted. A family history of AMD is often present, indicating shared genetic risk factors.
本研究旨在调查与视盘玻璃膜疣（ODD）相关的年龄相关性黄斑变性（AMD）风险。
这是一项观察性横断面研究。
参与者为神经眼科门诊有和没有ODD的连续患者。对10例合并ODD-AMD的患者进行了亚分析。
这两个队列是从2022年7月至2024年6月前瞻性招募的数据集中确定的。患者经眼科和影像学评估后获得ODD和AMD的正式诊断。使用逻辑回归模型计算AMD风险，以考虑人口统计学差异。
共确定了94例有ODD的患者（中位年龄：44岁[第一四分位数：20岁，第三四分位数：69岁]，64%为女性）和100例无ODD的患者（中位年龄：60岁[第一四分位数：44岁，第三四分位数：69岁]，48%为女性）。在有ODD和无ODD的队列中，AMD的发生率分别为9.6%和3%。有ODD组的AMD风险更高（比值比=3.93，95%置信区间：0.89-21.85，P=0.084）。尽管这种关联无统计学意义，但逻辑回归模型将其归因于两个队列之间的年龄差异。在10例ODD-AMD患者中，70%有AMD家族史。这些患者均为白种人，中位年龄为75岁（范围：56-91岁）；70%为女性。只有30%为吸烟者。在视盘成像中，70%的眼睛显示为中度至重度ODD。
与无ODD的患者相比，有ODD的患者可能患AMD的风险更高，可能有必要进行AMD筛查。通常存在AMD家族史，表明存在共同的遗传风险因素。
