Demirel Sibel, Yanık Özge, Özcan Gökçen, Batıoğlu Figen, Özmert Emin
Department of Ophthalmology, 63990Ankara University School of Medicine, Ankara, Turkey.
Eur J Ophthalmol. 2023 Jan;33(1):489-497. doi: 10.1177/11206721221124686. Epub 2022 Sep 7.
To define the choroidal morphological characteristics of non-exudative age-related macular degeneration (AMD) cases associated with acquired vitelliform lesions (AVLs).
This retrospective study included intermediate AMD patients with AVLs (Group1, 21eyes) and without AVLs (Group2, 21eyes). A healthy control group was (Group3, 23eyes) also included. Subfoveal choroidal thickness (SFCT), greatest basal diameter (GBD), and maximum height (MH) of the largest PED were measured on spectral domain optical coherence tomography. Internal reflectivity of PEDs and total choroidal area (TCA) were measured using ImageJ software. The TCA was binarized to the luminal area (LA) and stromal area. The choroidal vascularity index (CVI) was assessed.
The mean SFCT, TCA, and LA were higher in Group 1 (290.3 ± 86.8 μm, 0.840 ± 0.302 mm, 0.602 ± 0.227 mm) than in Group 2 (215.6 ± 85.0 μm, 0.594 ± 0.183 mm, 0.429 ± 0.139 mm) ( = 0.014, = 0.017, = 0.020, respectively). There was no significant difference in the CVI measurements between Group 1 and Group 2 (p = 1.000). The mean GBD and MH of the PED was higher in Group 1 (1443 ± 595 µm, 188 ± 86 µm) than in Group 2 (851 ± 368 µm, 119 ± 38 µm) ( = <0.001, = 0.001, respectively). Internal PED reflectivity was significantly lower in Group 1 (0.44 ± 0.21) than in Group 2 (0.66 ± 0.17) ( = <0.001). Internal PED reflectivity showed negative correlation with GBD and MH of the PED in Group 1 (r = -0.587, = 0.005; rho = -0.448, = 0.042, respectively). In Group 2, internal PED reflectivity had a negative correlation with MH of the PED (rho = -0.511, = 0.018).
Non-exudative AMD patients with AVLs are more prone to have a thick choroid and large hyporeflective PEDs as compared to the those without AVLs.
明确与获得性卵黄样病变（AVL）相关的非渗出性年龄相关性黄斑变性（AMD）病例的脉络膜形态特征。
这项回顾性研究纳入了伴有AVL的中度AMD患者（第1组，21只眼）和不伴有AVL的中度AMD患者（第2组，21只眼）。还纳入了一个健康对照组（第3组，23只眼）。在光谱域光学相干断层扫描上测量黄斑中心凹下脉络膜厚度（SFCT）、最大基底直径（GBD）和最大PED的最大高度（MH）。使用ImageJ软件测量PED的内部反射率和脉络膜总面积（TCA）。将TCA二值化为管腔面积（LA）和基质面积。评估脉络膜血管指数（CVI）。
第1组的平均SFCT、TCA和LA（分别为290.3±86.8μm、0.840±0.302mm、0.602±0.227mm）高于第2组（分别为215.6±85.0μm、0.594±0.183mm、0.429±0.139mm）（分别为p = 0.014、p = 0.017、p = 0.020）。第1组和第2组的CVI测量值无显著差异（p = 1.000）。第1组PED的平均GBD和MH（分别为1443±595μm、188±86μm）高于第2组（分别为851±368μm、119±38μm）（分别为p <0.001、p = 0.001）。第1组PED的内部反射率（0.44±0.21）显著低于第2组（0.66±0.17）（p <0.001）。第1组中，PED的内部反射率与PED的GBD和MH呈负相关（分别为r = -0.587，p = 0.005；rho = -0.448，p = 0.042）。在第2组中，PED的内部反射率与PED的MH呈负相关（rho = -0.511，p = 0.018）。
与不伴有AVL的非渗出性AMD患者相比，伴有AVL的患者更容易出现脉络膜增厚和大的低反射性PED。
