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微等离子体合成的碳量子点:抗菌性能与纳米探针灵敏度

Microplasma-synthesized -derived carbon quantum dots: antibacterial properties and nanoprobe sensitivity.

作者信息

Hoa Nguyen Minh, Toan Le Duc, Tran Ngo, Hung Le Xuan, Thi Le Anh

机构信息

Faculty of Fundamental Sciences, Hue University of Medicine and Pharmacy, Hue University Hue 530000 Vietnam.

Natural Sciences Department, Phu Yen University Tuy Hoa City Phu Yen 5600 Vietnam.

出版信息

RSC Adv. 2025 Jul 17;15(31):25362-25371. doi: 10.1039/d5ra02150b. eCollection 2025 Jul 15.

Abstract

This study introduces an environmentally friendly and cost-efficient approach for producing carbon quantum dots (CQDs) from a microplasma-assisted technique. The obtained CQDs demonstrated excitation-dependent fluorescence accompanied by a red shift, which can be ascribed to quantum size effects and the influence of surface chemical functionalities. The synthesized CQDs demonstrated remarkable antibacterial properties, achieving growth inhibition rates of 99.24% against and 98.12% against at a concentration of 50 μg mL. The antibacterial mechanism was primarily driven by membrane destabilization and oxidative stress induction, making CQDs a promising alternative to conventional antimicrobial agents. Additionally, the CQDs served as highly responsive fluorescent probes for Cd(ii) ion detection, exhibiting a linear response range spanning 1-14 μg mL, a minimum detectable concentration of 0.12 μg mL, and a Stern-Volmer quenching constant ( ) of 0.45 μg mL. These findings highlight the dual functionality of CQDs as potent antibacterial agents and efficient fluorescence-based sensors for heavy metal detection. The eco-friendly synthesis, combined with the excellent biocompatibility and adjustable optical characteristics of CQDs, highlights their potential for applications in biosensing, environmental monitoring, and biomedical fields.

摘要

本研究介绍了一种通过微等离子体辅助技术生产碳量子点(CQDs)的环保且经济高效的方法。所获得的碳量子点表现出依赖于激发的荧光并伴有红移,这可归因于量子尺寸效应和表面化学官能团的影响。合成的碳量子点表现出显著的抗菌性能,在浓度为50μg/mL时,对[具体菌种1]的生长抑制率达到99.24%,对[具体菌种2]的生长抑制率达到98.12%。抗菌机制主要由膜去稳定化和氧化应激诱导驱动,这使得碳量子点成为传统抗菌剂的有前景的替代品。此外,碳量子点作为用于检测Cd(ii)离子的高响应荧光探针,表现出1 - 14μg/mL的线性响应范围、0.12μg/mL的最低可检测浓度以及0.45μg/mL的斯特恩 - 沃尔默猝灭常数( )。这些发现突出了碳量子点作为强效抗菌剂和用于重金属检测的高效荧光传感器的双重功能。这种环保合成方法,结合碳量子点出色的生物相容性和可调节的光学特性,突出了它们在生物传感、环境监测和生物医学领域的应用潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f294/12268865/a6b2b806799d/d5ra02150b-s1.jpg

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