Kuu W Y, Yalkowsky S H
J Pharm Sci. 1985 Sep;74(9):926-33. doi: 10.1002/jps.2600740904.
We describe an approach to zero-order drug delivery systems that utilizes a device consisting of multiple holes uniformly distributed in an impermeable membrane. The interior of the device is filled with a suspension of a drug in a polymeric matrix. Near zero-order release is attained by using the proper density and configuration of holes on the surface of the device.
我们描述了一种用于零级药物递送系统的方法，该方法利用一种由均匀分布在不透性膜中的多个孔组成的装置。该装置内部填充有药物在聚合物基质中的悬浮液。通过使用装置表面孔的适当密度和配置可实现近零级释放。
