Kato Shigeki, Sugawara Masateru, Yamasaki Miwako, Watanabe Masahiko, Inoue Ken-Ichi, Nakamura Katsuki, Koketsu Daisuke, Chiken Satomi, Nambu Atsushi, Takada Masahiko, Kobayashi Kazuto
Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
iScience. 2025 Jun 17;28(7):112921. doi: 10.1016/j.isci.2025.112921. eCollection 2025 Jul 18.
The cortico-basal ganglia circuitry plays important roles in the control of various higher-order functions, such as motor control, cognition, and emotion. The thalamostriatal system is involved in learning and switching of behaviors and recovery from cognitive and motor deficits in rodents. Here, we applied selective neural pathway targeting to investigate roles of two representative thalamostriatal pathways arising from the parafascicular nucleus (Pf) and centre médian nucleus (CM) in common marmosets. Targeting of the Pf projecting to the caudate (Cd) resulted in impaired reversal of learned responses in a visual discrimination task, showing increased perseverative errors during the reversal phase. Targeting the CM innervating the putamen (Pu) disturbed acquisition of the visual discrimination. In contrast, elimination of the Pf-Cd or CM-Pu pathway did not alter performance of motor skill learning. Our results indicate that these two thalamostriatal pathways have distinct roles in learning processes of sensory cue-dependent decision-making in nonhuman primates.
皮质-基底神经节回路在控制各种高级功能中发挥着重要作用，如运动控制、认知和情感。丘脑纹状体系统参与啮齿动物行为的学习和转换以及从认知和运动缺陷中恢复。在此，我们应用选择性神经通路靶向技术，研究普通狨猴中源自束旁核（Pf）和中央中核（CM）的两条代表性丘脑纹状体通路的作用。靶向投射到尾状核（Cd）的Pf会导致视觉辨别任务中习得反应的反转受损，在反转阶段出现更多的持续性错误。靶向支配壳核（Pu）的CM会干扰视觉辨别的习得。相比之下，消除Pf-Cd或CM-Pu通路不会改变运动技能学习的表现。我们的结果表明，这两条丘脑纹状体通路在非人灵长类动物依赖感觉线索的决策学习过程中具有不同的作用。
