Siddiqui Khalid, Nawaz Shaik Sarfaraz, George Teena P, David Satish Kumar, Alfadda Assim A, Rafiullah Mohamed
Strategic Center for Diabetes Research, College of Medicine, King Saud University, P.O. Box 245, Riyadh, 11411 KSA Saudi Arabia.
Department of Biochemistry, College of Medicine, Kuwait University, Kuwait, 13060 Kuwait.
J Diabetes Metab Disord. 2025 Jul 15;24(2):171. doi: 10.1007/s40200-025-01680-y. eCollection 2025 Dec.
Type 2 diabetes(T2D) patients are at the greatest risk of developing kidney disease. The triglyceride glucose index (TyG index) is considered a simple marker of insulin resistance. Its role in the progression of diabetes kidney disease (DKD) in T2D is unclear. We wanted to see if the TyG index could accurately predict the beginning of DKD. The study aimed to investigate the association of the TyG index with DKD progression in T2D.
428 T2D patients with and without DKD were included. DKD progression was defined according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. Patient demographic data were divided into quartiles according to the TyG index. Multiple regression was used to analyze the association between the TyG Index and metabolic indicators.
The results showed that 257 participants (60.0%) developed DKD. Subjects in the DKD group had a significantly higher TyG index than those without the DKD group (9.9 ± 0.7 vs. 9.4 ± 0.6, < 0.001). The DKD group had longer disease duration, higher age, systolic blood pressure, glycated haemoglobin, triglycerides, total cholesterol, urea, uric acid, creatinine, LDH, albumin creatinine ratio, TyG index ( < 0.05 for each), and lower eGFR. An increased TyG index was shown to be an independent risk factor for DKD.
The TyG Index is a potential indicator for DKD in T2D individuals. This finding supports the clinical utility of the TyG index in assessing renal function deterioration in individuals with DKD.
2型糖尿病（T2D）患者发生肾脏疾病的风险最高。甘油三酯葡萄糖指数（TyG指数）被认为是胰岛素抵抗的一个简单标志物。其在T2D患者糖尿病肾病（DKD）进展中的作用尚不清楚。我们想了解TyG指数是否能准确预测DKD的发病。本研究旨在探讨TyG指数与T2D患者DKD进展之间的关联。
纳入428例有或无DKD的T2D患者。根据改善全球肾脏病预后组织（KDIGO）标准定义DKD进展。患者人口统计学数据根据TyG指数分为四分位数。采用多元回归分析TyG指数与代谢指标之间的关联。
结果显示，257名参与者（60.0%）发生了DKD。DKD组受试者的TyG指数显著高于无DKD组（9.9±0.7 vs. 9.4±0.6，P<0.001）。DKD组的病程更长，年龄、收缩压、糖化血红蛋白、甘油三酯、总胆固醇、尿素、尿酸、肌酐、乳酸脱氢酶、白蛋白肌酐比值、TyG指数更高（每项P<0.05），而估算肾小球滤过率更低。TyG指数升高被证明是DKD的一个独立危险因素。
TyG指数是T2D个体发生DKD的一个潜在指标。这一发现支持了TyG指数在评估DKD个体肾功能恶化方面的临床应用价值。
