Hua Weilong, Wang Lijun, Xu Hongye, Ma Hongyu, Zhang Yongxin, Shen Hongjian, Zhang Xiaoxi, Xing Pengfei, Yang Pengfei
Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
No. 904 Hospital of the PLA Joint Logistics Support Force, Wuxi, China.
Future Sci OA. 2025 Dec;11(1):2534329. doi: 10.1080/20565623.2025.2534329. Epub 2025 Jul 18.
Patients with systemic lupus erythematosus (SLE) typically have an increased risk of thrombosis, especially at a younger age. The prognosis of those acute ischemic stroke (AIS) patients due to acute intracranial artery occlusion seems to be favorable; however, with few published reports. We report two cases of AIS that were treated with intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) with a prior diagnosis of SLE and were treated with regular oral corticosteroids before the onset. During the 1-year follow-up, these two patients were able to live normally without experiencing another ischemic stroke or changing medication. SLE-associated strokes necessitate urgent attention, with prompt diagnosis and immediate therapeutic measures, including thrombolytic therapy or MT, being crucial for achieving favorable patient outcomes.
系统性红斑狼疮(SLE)患者通常血栓形成风险增加,尤其是在较年轻的时候。那些因急性颅内动脉闭塞导致急性缺血性卒中(AIS)的患者预后似乎较好;然而,相关发表报告较少。我们报告两例AIS患者,他们在发病前已确诊SLE并接受常规口服糖皮质激素治疗,此次接受了静脉溶栓(IVT)和机械取栓(MT)治疗。在1年的随访期间,这两名患者能够正常生活,未再发生缺血性卒中,也未改变用药。SLE相关卒中需要紧急关注,迅速诊断并立即采取治疗措施,包括溶栓治疗或MT,对于实现良好的患者预后至关重要。