Yakubets D A, Rudimova Yu V, Buravkova L B
Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Bull Exp Biol Med. 2025 May;179(1):6-9. doi: 10.1007/s10517-025-06422-x. Epub 2025 Jul 18.
Long-term space flights induce adaptive changes in almost all tissues and organs. To elucidate adaptive mechanisms at the molecular and cellular levels, it is important to analyze transcriptional shifts in response to weightlessness/microgravity. Here we examined the transcriptomic profile of mouse lung tissue after a long-term space mission as part of the NASA Rodent Research scientific program. We identified 45 differentially expressed genes. G-protein-coupled olfactory and vomeronasal receptor encoding genes were found to be "ectopically" upregulated. Most of the downregulated genes are responsible for protein folding and regulation of circadian rhythms. The obtained data confirm the low level of gravity sensitivity of lung cells and their high adaptive potential under conditions of prolonged space flight.
长期太空飞行会在几乎所有组织和器官中引发适应性变化。为了在分子和细胞水平上阐明适应机制，分析对失重/微重力的转录变化非常重要。作为美国国家航空航天局啮齿动物研究科学计划的一部分，我们在此研究了长期太空任务后小鼠肺组织的转录组概况。我们鉴定出45个差异表达基因。发现编码G蛋白偶联嗅觉和犁鼻器受体的基因“异位”上调。大多数下调基因负责蛋白质折叠和昼夜节律调节。所获得的数据证实了肺细胞的重力敏感性较低，以及在长期太空飞行条件下它们具有较高的适应潜力。
