Sanchez-Rodriguez Dolores, Bellanger Amelie, Iconaru Laura, Baleanu Felicia, Hambye Anne-Sophie, de Filette Jeroen, Mugisha Aude, Benoit Florence, Surquin Murielle, Bergmann Pierre, Body Jean-Jacques
Geriatrics Department, CHU Brugmann, Université Libre de Bruxelles, Place A. Van Gehuchten 4 (Bât K - OK11), 1020, Brussels, Belgium.
Rehabilitation Research Group, Hospital del Mar Research Institute, Barcelona, Spain.
Eur Geriatr Med. 2025 Jul 18. doi: 10.1007/s41999-025-01273-1.
We assessed the associations between osteosarcopenia, sarcopenia (according to seven definitions), and the presence of radiologically validated recent osteoporotic fractures in community-dwelling older women from the Fracture Risk Brussels Epidemiological Enquiry (FRISBEE2) study.
Retrospective cohort design. The FRISBEE2 study includes 907 community-dwelling women aged 77 (75-81) years. Sarcopenia (according to six consensual definitions: EWGSOP2 "probable" and "confirmed"; IWGS; SCWD; SDOC; FNIH, and as seventh, an exploratory, potential framework for the GLIS), osteoporosis (T-score ≤ - 2.5SD), and osteosarcopenia (osteoporosis plus each of the 7 sarcopenia definitions) were assessed at baseline. We recorded and radiologically validated recent (i.e., within 2 years before baseline) central or major osteoporotic fractures (MOFs). Multivariate regression models adjusted for age, BMI, sedentary lifestyle, and comorbidities, were used to evaluate associations between osteosarcopenia and sarcopenia at baseline with the presence of recent fractures.
As expected, the prevalence of osteosarcopenia and sarcopenia varied widely depending on the definitions used. Out of the 907 included women, 47 (5.2%) had experienced a recent fracture. The crude analysis showed significant associations between osteosarcopenia, osteoporosis, and sarcopenia and the presence of recent fractures. In the multivariate analysis, only EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength) was associated with recent fractures [OR = 2.14 (1.05-4.35); p = 0.035].
Older women with a history of recent fracture had EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength). A recent central or MOF should alert on probable sarcopenia. Further prospective studies are needed to explore the role of muscle strength as a modifiable risk factor for fractures.
在“布鲁塞尔骨折风险流行病学调查（FRISBEE2）”研究中，我们评估了社区居住老年女性中骨质疏松性肌少症、肌少症（根据七种定义）与经放射学验证的近期骨质疏松性骨折的存在之间的关联。
采用回顾性队列设计。FRISBEE2研究纳入了907名年龄为77（75 - 81）岁的社区居住女性。在基线时评估肌少症（根据六种共识定义：EWGSOP2“可能”和“确诊”；IWGS；SCWD；SDOC；FNIH，以及作为第七种的GLIS探索性潜在框架）、骨质疏松症（T评分≤ - 2.5标准差）和骨质疏松性肌少症（骨质疏松症加上7种肌少症定义中的每一种）。我们记录并通过放射学验证了近期（即基线前2年内）的椎体或主要骨质疏松性骨折（MOF）。使用针对年龄、体重指数、久坐生活方式和合并症进行调整的多变量回归模型，来评估基线时骨质疏松性肌少症和肌少症与近期骨折存在之间的关联情况。
正如预期的那样，骨质疏松性肌少症和肌少症的患病率因所使用的定义而有很大差异。在纳入的907名女性中，47名（5.2%）经历过近期骨折。粗分析显示骨质疏松性肌少症、骨质疏松症和肌少症与近期骨折的存在之间存在显著关联。在多变量分析中，只有EWGSOP2定义的可能肌少症（即握力低）与近期骨折相关[比值比 = 2.14（1.05 - 4.35）；p = 0.035]。
有近期骨折史的老年女性存在EWGSOP2定义的可能肌少症（即握力低）。近期的椎体或主要骨质疏松性骨折应提示可能存在肌少症。需要进一步的前瞻性研究来探讨肌肉力量作为骨折可改变危险因素的作用。
