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[突发性耳聋的治疗:一项对比研究的初步结果]

[(Treatment of sudden deafness: first results of a comparative study)].

作者信息

Dauman R, Cros A M, Poisot D

出版信息

J Otolaryngol. 1985 Feb;14(1):49-56.

PMID:4068091
Abstract

A comparative study is undertaken in 36 cases of sudden deafness in order to appreciate the efficiency of three therapies: vaso-active drug and steroid administered through continuous perfusions, normovolemic hemodilution, and hyperbaric oxygen therapy. Groups are homogeneous with respect to age, time elapsed between onset of deafness and treatment, occurrence of vertigo, degree of hearing loss, and audiometric pattern. Results are expressed in terms of pure tone threshold improvement (dB), audiometric ratio recovery taking into account initial hearing loss, and effects upon tinnitus. These data are complemented with electrophysiological measures (click-evoked electrocochleography and auditory brainstem responses). Analysis of variance does not show significant differences among the three procedures. Mechanisms and possible usefulness are discussed, keeping in mind the difficulty of ascertaining the real efficiency of therapies with respect to spontaneous recovery.

摘要

对36例突发性聋患者进行了一项比较研究,以评估三种治疗方法的疗效:通过持续灌注给予血管活性药物和类固醇、等容血液稀释疗法以及高压氧疗法。各治疗组在年龄、耳聋发作至治疗的时间间隔、眩晕的发生情况、听力损失程度以及听力图模式方面具有同质性。结果以纯音阈值改善(dB)、考虑初始听力损失的听力比率恢复情况以及对耳鸣的影响来表示。这些数据还辅以电生理测量(短声诱发的耳蜗电图和听觉脑干反应)。方差分析显示三种治疗方法之间没有显著差异。在考虑到确定治疗相对于自发恢复的实际疗效存在困难的情况下,对其机制和可能的实用性进行了讨论。

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