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使用基于蒙特卡洛的模型和实验验证来表征和最小化诊断X射线束校准中的不确定性。

Characterizing and minimizing uncertainties in diagnostic X-ray beam calibrations using a Monte Carlo-based model and experimental validation.

作者信息

Abarane Abdelouahab, Bougteb Mustapha, Zidouz Taibi, Talbi Abdellatif, Allach Abderrahim, Mkimel Mounir, Zaryah Mohamed, Mesradi Mohammed Reda, Ardouz Anas, El Baydaoui Redouane

机构信息

Sciences and Engineering of Biomedicals, Biophysics and Health Laboratory, Hassan First University, Higher Institute of Health Sciences, 26000, Settat, Morocco.

LEGX, Laboratoire d'Etalonnage Gamma Et X, Centre National de L'Energie, Des Sciences Et Des Techniques Nucléaires, Rabat, Morocco.

出版信息

Radiol Phys Technol. 2025 Jul 18. doi: 10.1007/s12194-025-00943-w.

DOI:10.1007/s12194-025-00943-w
PMID:40681944
Abstract

This study aims to develop a flexible Geant4 application capable of modeling all IEC 61267 defined radiation qualities for the HOPEWELL Designs 225 kV X-ray generator, while systematically analyze the impact of various environmental and systematic factors. Using Geant4, we replicated the experimental setup of the LEGEX laboratory and simulated all IEC 61267 radiation qualities by adjusting relevant beam parameters. The model was validated by comparing simulated HVLs and spectra, measured with a CdTe X-123 spectrometer against experimental data, SRS78 software results, and IEC reference values. The simulation demonstrated strong agreement with experimental measurements and published data, confirming the validity of our Geant4 application. We derived the function that characterizes the behavior of Kinetic Energy Released per unit Mass (KERMA) in response to variations in each influencing factor. Geometrical misalignment is the primary contributor to deviations, followed by aluminum purity and diaphragm movement, while environmental factors induced minor fluctuations. Additionally, we quantified backscattered radiation and applied corrective measures to eliminate its impact on measurements. The developed Geant4 application provides a reliable tool for simulating IEC 61267 radiation qualities and optimizing dosimetric accuracy. Our framework offers a cost-effective alternative to replicate different scenarios multiple times to identify and minimizes uncertainties.

摘要

本研究旨在开发一个灵活的Geant4应用程序,该程序能够对HOPEWELL Designs 225 kV X射线发生器的所有IEC 61267定义的辐射质量进行建模,同时系统地分析各种环境和系统因素的影响。我们使用Geant4复制了LEGEX实验室的实验装置,并通过调整相关束参数模拟了所有IEC 61267辐射质量。通过将用碲化镉X-123光谱仪测量的模拟半值层和光谱与实验数据、SRS78软件结果以及IEC参考值进行比较,对模型进行了验证。模拟结果与实验测量值和已发表数据高度吻合,证实了我们的Geant4应用程序的有效性。我们推导了表征单位质量释动能(KERMA)随每个影响因素变化的行为的函数。几何失准是偏差的主要来源,其次是铝纯度和光阑移动,而环境因素引起的波动较小。此外,我们对反向散射辐射进行了量化,并采取了校正措施以消除其对测量的影响。所开发的Geant4应用程序为模拟IEC 61267辐射质量和优化剂量学准确性提供了一个可靠的工具。我们的框架提供了一种经济高效的替代方案,可多次复制不同场景以识别并最小化不确定性。

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