Zhang Mingzhao, Wang Yang, Zou Yong, Zhi Weijia, Zhao Xuelong, Niu Jiajia, Du Lina, Ma Lizhen, Wang Lifeng
Beijing Institute of Radiation Medicine, Beijing, China.
Hebei Chemical & Pharmaceutical College, Hebei, China.
Neurochem Res. 2025 Jul 19;50(4):238. doi: 10.1007/s11064-025-04480-1.
Microwave radiation is extremely sensitive to the brain and has been shown in animal models to affect memory and learning. Brain-derived neurotrophic factor (BDNF) is essential for neural function and brain development, with many single nucleotide polymorphisms (SNPs) in gene. Several neuropathological disorders have been linked to the BDNF Val66Met variation. Using CRISPR, we created BDNF Val76Met mutations in rats in this study. The rats were then subjected to X-band and S-band microwave radiation, respectively, at an average power density of 50 mW/cm² for 15 min every day for five days. We assessed cognitive capacity and investigated the neural structure and BDNF mRNA levels in the brain of rats. We discovered that BDNF Val76Met rats had impaired learning capacity and altered brain structure, with a decrease in BDNF mRNA. Meanwhile, we found that BDNF Val76Met rats exhibited aggravated structural and functional brain damage under 50mW/cm microwave radiation, and showed higher sensitivity to S-band microwave due to the stronger penetration compared to X-band microwaves. Considering the genetic differences between animals and humans, more research is needed to determine the exact mechanism by which this SNP location affects cognitive changes caused by microwave radiation.
微波辐射对大脑极为敏感，在动物模型中已显示会影响记忆和学习。脑源性神经营养因子（BDNF）对神经功能和大脑发育至关重要，其基因存在许多单核苷酸多态性（SNP）。几种神经病理学疾病已与BDNF Val66Met变异相关联。在本研究中，我们使用CRISPR在大鼠中创建了BDNF Val76Met突变。然后分别对大鼠进行X波段和S波段微波辐射，平均功率密度为50 mW/cm²，每天15分钟，持续五天。我们评估了大鼠的认知能力，并研究了其大脑的神经结构和BDNF mRNA水平。我们发现BDNF Val76Met大鼠的学习能力受损且大脑结构改变，BDNF mRNA减少。同时，我们发现BDNF Val76Met大鼠在50mW/cm微波辐射下表现出更严重的大脑结构和功能损伤，并且由于S波段微波比X波段微波具有更强的穿透力，所以对S波段微波表现出更高的敏感性。考虑到动物与人类之间的基因差异，需要更多研究来确定该SNP位点影响微波辐射所致认知变化的确切机制。
