Hao Shiping, Mei Yongming, Chen Shaolin, Liu Jing, Zhang Yao, Zhu Zhengfeng, Zuo Kangjia
The Public Experimental Center of Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China.
Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China.
Oncol Rep. 2025 Oct;54(4). doi: 10.3892/or.2025.8950. Epub 2025 Jul 19.
Post‑translational modifications (PTMs) of proteins, by altering the structural conformation of precursor polypeptides, play an indispensable role in augmenting the diversity and stability of the proteome. PTMs exert profound influence on various hallmarks of tumor biology, including cellular proliferation, apoptosis, angiogenesis and metastatic dissemination. Accordingly, advancing our understanding of PTMs holds substantial promise for broadening the therapeutic landscape of oncology. Among these modifications, palmitoylation, a reversible lipid‑based PTM, critically modulates protein stability, membrane localization, protein‑protein interactions and signal transduction cascades. Dysregulation of palmitoylation has been increasingly implicated in tumorigenesis, suggesting its aberrant forms as putative targets for therapeutic intervention. The present review delineates the biochemical mechanisms underlying protein palmitoylation and synthesizes current insights into its multifaceted roles in tumor progression, immune modulation and metabolic regulation, thereby offering novel perspectives for the development of targeted cancer therapies.
蛋白质的翻译后修饰（PTMs）通过改变前体多肽的结构构象，在增加蛋白质组的多样性和稳定性方面发挥着不可或缺的作用。PTMs对肿瘤生物学的各种特征产生深远影响，包括细胞增殖、凋亡、血管生成和转移扩散。因此，加深我们对PTMs的理解对于拓宽肿瘤学治疗前景具有重大意义。在这些修饰中，棕榈酰化是一种可逆的基于脂质的PTM，它对蛋白质稳定性、膜定位、蛋白质-蛋白质相互作用和信号转导级联反应起着关键的调节作用。棕榈酰化失调越来越多地与肿瘤发生相关，这表明其异常形式可作为治疗干预的潜在靶点。本综述阐述了蛋白质棕榈酰化的生化机制，并综合了目前对其在肿瘤进展、免疫调节和代谢调节中的多方面作用的见解，从而为开发靶向癌症治疗提供了新的视角。
