Gallego-Landin Ines, Berbegal-Sáez Paula, Valverde Olga
Neurobiology of Behavior Research Group (GReNeC-NeuroBio), Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra, Barcelona, Spain.
Neurosciences Program, Hospital del Mar Medical Research Institute, Barcelona, Spain.
Sci Rep. 2025 Jul 19;15(1):26291. doi: 10.1038/s41598-025-12237-7.
Chronodisruption, the misalignment of internal biological systems with external environmental changes, negatively impacts health and cognition. A prevalent form, social jet lag, affects a large portion of adolescents and is associated with reduced academic performance, and impaired emotional regulation. Despite its prevalence, the mechanism by which adolescent chronodisruption results in cognitive deficits remains unexplored. Here, we induced chronic chronodisruption in adolescent mice through light/dark cycle manipulation. We performed a battery of established behavioral tests alongside an analysis of daily rhythms of expression of genes involved in relevant physiological functions. We report that adolescent circadian disruption induces impairments in short-term, social, and spatial memory without prompting anxiety-like behavior. Gene expression analyses revealed altered oscillation patterns of circadian clock genes in the hypothalamus and hippocampus. Furthermore, we identified alterations in daily patterns of genes involved in glucocorticoid and endocannabinoid transmissions as well as synaptic plasticity. This work emphasizes the importance of circadian homeostasis for cognitive function and hippocampal homeostasis. Thus, understanding the mechanism underlying adolescent chronodisruption is essential to better understand its long-term implications for cognitive function and overall health.
昼夜节律紊乱，即内部生物系统与外部环境变化失调，会对健康和认知产生负面影响。一种常见的形式是社会时差，它影响着很大一部分青少年，并与学业成绩下降和情绪调节受损有关。尽管其很普遍，但青少年昼夜节律紊乱导致认知缺陷的机制仍未得到探索。在这里，我们通过光/暗周期操纵在青少年小鼠中诱导慢性昼夜节律紊乱。我们进行了一系列既定的行为测试，并分析了参与相关生理功能的基因的每日表达节律。我们报告说，青少年昼夜节律紊乱会导致短期、社交和空间记忆受损，而不会引发类似焦虑的行为。基因表达分析揭示了下丘脑和海马体中昼夜节律基因振荡模式的改变。此外，我们发现参与糖皮质激素和内源性大麻素传递以及突触可塑性的基因的每日模式发生了变化。这项工作强调了昼夜节律稳态对认知功能和海马体稳态的重要性。因此，了解青少年昼夜节律紊乱背后的机制对于更好地理解其对认知功能和整体健康的长期影响至关重要。
