二氢叶酸还原酶中的活性中心色氨酸残基：化学修饰、关键残基周围的序列以及结构同源性考量 - Suppr | 超能文献

An active center tryptophan residue in dihydrofolate reductase: chemical modification, sequence surrounding the critical residue, and structural homology considerations.

作者信息

Freisheim J H, Ericsson L H, Bitar K G, Dunlap R B, Reddy A V

出版信息

Arch Biochem Biophys. 1977 Apr 30;180(2):310-7. doi: 10.1016/0003-9861(77)90043-1.

DOI:10.1016/0003-9861(77)90043-1

Abstract

摘要

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An active center tryptophan residue in dihydrofolate reductase: chemical modification, sequence surrounding the critical residue, and structural homology considerations.二氢叶酸还原酶中的活性中心色氨酸残基：化学修饰、关键残基周围的序列以及结构同源性考量

Arch Biochem Biophys. 1977 Apr 30;180(2):310-7. doi: 10.1016/0003-9861(77)90043-1.

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Implication of a tryptophyl residue in the active site of dihydrofolate reductase.色氨酸残基在二氢叶酸还原酶活性位点中的作用。

Biochemistry. 1974 Apr 23;13(9):1807-14. doi: 10.1021/bi00706a005.

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Dihydrofolate reductase from Lactobacillus casei: N-terminal sequence and comparison with the substrate binding region of other reductases.干酪乳杆菌的二氢叶酸还原酶：N端序列及与其他还原酶底物结合区域的比较。

Biochem Biophys Res Commun. 1977 Apr 25;75(4):1010-4. doi: 10.1016/0006-291x(77)91482-6.

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Amino acid sequence of dihydrofolate reductase from an amethopterin-resistant strain of Lactobacillus casei.来自一株氨甲蝶呤抗性干酪乳杆菌的二氢叶酸还原酶的氨基酸序列。

FEBS Lett. 1977 Aug 1;80(1):119-22. doi: 10.1016/0014-5793(77)80420-1.

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Interaction of dihydrofolate reductase from amethopterin-resistant Lactobacillus casei with Cibacron Blue, Blue Dextran, and Affi-Gel Blue.来自氨甲蝶呤抗性干酪乳杆菌的二氢叶酸还原酶与汽巴克隆蓝、蓝色葡聚糖及亲和凝胶蓝的相互作用

J Biol Chem. 1979 Jul 25;254(14):6515-21.

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Reduction of oxidised folates by dihydrofolate reductase from methotrexate-resistant Lactobacillus casei.来自耐甲氨蝶呤干酪乳杆菌的二氢叶酸还原酶对氧化型叶酸的还原作用

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Effect of N-bromosuccinimide modification on dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli. Activity, spectrophotometric, fluorescence and circular dichroism studies.N-溴代琥珀酰亚胺修饰对来自耐甲氨蝶呤大肠杆菌菌株的二氢叶酸还原酶的影响。活性、分光光度法、荧光和圆二色性研究。

J Biol Chem. 1975 Jan 10;250(1):322-30.

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Nucleotide sequence of the dihydrofolate reductase gene of methotrexate-resistant Lactobacillus casei.耐甲氨蝶呤干酪乳杆菌二氢叶酸还原酶基因的核苷酸序列

Gene. 1985;35(1-2):217-22. doi: 10.1016/0378-1119(85)90174-x.

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Functional arginine residues involved in coenzyme binding by dihydrofolate reductase.

Biochem Biophys Res Commun. 1976 Feb 9;68(3):937-41. doi: 10.1016/0006-291x(76)91235-3.

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Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei. Effects of pH, salts, temperature, and source of NADPH on enzyme activity and substrate specificity studies.来自抗氨甲蝶呤干酪乳杆菌的二氢叶酸还原酶。pH值、盐类、温度以及NADPH来源对酶活性的影响和底物特异性研究。

Arch Biochem Biophys. 1977 Jun;181(2):569-79. doi: 10.1016/0003-9861(77)90263-6.

引用本文的文献

1

The effects of modification with N-bromosuccinimide on the binding of ligands to dihydrofolate reductase.N-溴代琥珀酰亚胺修饰对配体与二氢叶酸还原酶结合的影响。

Biochem J. 1980 May 1;187(2):501-6. doi: 10.1042/bj1870501.

2

Circular-dichroism studies of ligand binding to dihydrofolate reductase from Lactobacillus casei MTX/R.配体与干酪乳杆菌MTX/R二氢叶酸还原酶结合的圆二色性研究。

Biochem J. 1979 Feb 1;177(2):425-32. doi: 10.1042/bj1770425.

3

Ultraviolet difference-spectroscopic studies of substrate and inhibitor binding to Lactobacillus casei dihydrofolate reductase.底物和抑制剂与干酪乳杆菌二氢叶酸还原酶结合的紫外差光谱研究。

Biochem J. 1978 May 1;171(2):357-66. doi: 10.1042/bj1710357.