Bakhshi-Ameshi Shiva, Torabi Nihad, Nazari Maryam, Eliassi Afsaneh
Department of Physiology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Brain Res. 2025 Sep 15;1863:149846. doi: 10.1016/j.brainres.2025.149846. Epub 2025 Jul 18.
The ventromedial hypothalamus (VMH) is recognized for its critical role in regulating feeding behavior and maintaining energy homeostasis. This study investigates the involvement of dopamine D1-like receptors within the VMH in modulating food intake following 24-hour fasting in male Wistar rats. Using selective intra-VMH D1-like receptor activation via SKF38393 and antagonism via SCH23390, we assessed the effects of VMH dopamine D1-like receptors on food consumption. Results demonstrated a dose-dependent increase in food intake following SKF38393 administration, an effect significantly attenuated by SCH23390 as a selective D1-like receptor antagonist. This suggests that VMH D1-like receptors contribute to the regulation of feeding behavior in fasted states. In addition, we determined that this response was independent of locomotor activity. The study advances our understanding of hypothalamic dopamine pathways in appetite regulation, highlighting VMH D1-like receptors as a potential target for interventions in metabolic disorders.
腹内侧下丘脑（VMH）因其在调节进食行为和维持能量平衡方面的关键作用而被认可。本研究调查了雄性Wistar大鼠禁食24小时后，VMH内多巴胺D1样受体在调节食物摄入量中的作用。通过SKF38393进行VMH内选择性D1样受体激活以及通过SCH23390进行拮抗，我们评估了VMH多巴胺D1样受体对食物消耗的影响。结果表明，给予SKF38393后食物摄入量呈剂量依赖性增加，作为选择性D1样受体拮抗剂的SCH23390显著减弱了这一效应。这表明VMH D1样受体有助于在禁食状态下调节进食行为。此外，我们确定这种反应与运动活动无关。该研究推进了我们对下丘脑多巴胺通路在食欲调节中的理解，突出了VMH D1样受体作为代谢紊乱干预潜在靶点的作用。
