Yang Pei-Li, Zheng Li-Rong, Zhao Ying-Qiang
Graduate School, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300250, China.
Zhongguo Zhong Yao Za Zhi. 2025 Jun;50(12):3232-3243. doi: 10.19540/j.cnki.cjcmm.20250310.602.
Heart failure(HF) is the terminal stage of various cardiovascular diseases, characterized by high morbidity and mortality, and it represents one of the major disease burdens for families and society. In recent years, as research on the molecular mechanisms of HF has deepened, a competing endogenous RNA(ceRNA) network mediated by long non-coding RNAs(lncRNAs) and circular RNAs(circRNAs) has been gradually constructed. Extensive research results have confirmed that the ceRNA network is widely involved in pathological processes such as inflammation, oxidative stress, myocardial hypertrophy, apoptosis, remodeling of extracellular matrix components and structure, and ferroptosis in HF. It reveals the complex pathological mechanisms of HF at the epigenetic level. Traditional Chinese medicine(TCM) plays a unique role in improving symptoms and prognosis of HF and intervenes in the ceRNA network in HF through multi-level and multi-target mechanisms. It improves key pathological processes such as myocardial fibrosis and inflammation, making progress in treating HF at the molecular level. This article summarized recent Chinese and international research on the regulatory mechanisms of ceRNA networks in HF, elaborated on the mechanisms of action of ceRNA networks in different pathological stages of HF, and summarized how effective components and compounds of TCM intervene in the ceRNA network to improve HF, so as to refine the molecular mechanisms of HF and provide directions for more precise molecular targeted therapeutic strategies.
心力衰竭（HF）是各种心血管疾病的终末期，具有高发病率和高死亡率的特点，是家庭和社会的主要疾病负担之一。近年来，随着对HF分子机制研究的深入，由长链非编码RNA（lncRNAs）和环状RNA（circRNAs）介导的竞争性内源RNA（ceRNA）网络逐渐构建起来。大量研究结果证实，ceRNA网络广泛参与HF中的炎症、氧化应激、心肌肥大、细胞凋亡、细胞外基质成分和结构重塑以及铁死亡等病理过程。它在表观遗传水平揭示了HF复杂的病理机制。中医在改善HF症状和预后方面发挥着独特作用，并通过多层次、多靶点机制干预HF中的ceRNA网络。它改善心肌纤维化和炎症等关键病理过程，在HF的分子水平治疗上取得进展。本文综述了近期国内外关于HF中ceRNA网络调控机制的研究，阐述了ceRNA网络在HF不同病理阶段的作用机制，并总结了中药有效成分和化合物如何干预ceRNA网络以改善HF，从而细化HF的分子机制，为更精准的分子靶向治疗策略提供方向。
