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复发性前列腺间质肉瘤(PSS):一例病例报告及文献综述。

Recurrent prostatic stromal sarcoma (PSS): A case report and literature review.

作者信息

Nowroozi Mohammad Reza, Madani Mohammad Hamidi, Farzin Amirreza, Montazeri Saeed, Torkamani Zahra Tahamtani, Hajiasadi Ehsan

机构信息

Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Urol Case Rep. 2025 Jul 4;62:103118. doi: 10.1016/j.eucr.2025.103118. eCollection 2025 Sep.

DOI:10.1016/j.eucr.2025.103118
PMID:40686513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12272748/
Abstract

Prostatic stromal sarcoma (PSS) is an exceptionally rare mesenchymal tumor of the prostate. We present a case of high-grade recurrent PSS in a 49-year-old man, managed with complete surgical excision and successful organ preservation. This report is accompanied by a literature review highlighting diagnostic challenges, histopathological features, and evolving surgical approaches, including robotic-assisted techniques. By comparing our case with previously reported cases, we emphasize the importance of individualized treatment strategies and long-term follow-up in managing this aggressive malignancy.

摘要

前列腺基质肉瘤(PSS)是一种极其罕见的前列腺间叶肿瘤。我们报告一例49岁男性的高级别复发性PSS病例,通过完整手术切除成功保留了器官。本报告还伴有文献综述,重点介绍了诊断挑战、组织病理学特征以及不断发展的手术方法,包括机器人辅助技术。通过将我们的病例与先前报道的病例进行比较,我们强调了个体化治疗策略和长期随访在管理这种侵袭性恶性肿瘤中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aee/12272748/35eb9d3d1da1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aee/12272748/01a940174b48/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aee/12272748/39c648ac6f8c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aee/12272748/35eb9d3d1da1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aee/12272748/01a940174b48/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aee/12272748/39c648ac6f8c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aee/12272748/35eb9d3d1da1/gr3.jpg

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本文引用的文献

1
A case of stromal sarcoma of the prostate with the incidental detection of prostate adenocarcinoma.一例前列腺间质肉瘤伴偶然发现前列腺腺癌。
Urol Case Rep. 2025 Jan 28;59:102963. doi: 10.1016/j.eucr.2025.102963. eCollection 2025 Mar.
2
Primary Prostatic Stromal Sarcoma: A Case Report and Review of the Literature.原发性前列腺间质肉瘤:一例报告及文献复习
Medicina (Kaunas). 2024 Nov 22;60(12):1918. doi: 10.3390/medicina60121918.
3
Practical Approach to Histological Diagnosis of Peripheral Nerve Sheath Tumors: An Update.
外周神经鞘瘤组织学诊断的实用方法:最新进展
Diagnostics (Basel). 2022 Jun 14;12(6):1463. doi: 10.3390/diagnostics12061463.
4
Pediatric Rhabdomyosarcoma: Epidemiology and Genetic Susceptibility.小儿横纹肌肉瘤:流行病学与遗传易感性
J Clin Med. 2021 May 9;10(9):2028. doi: 10.3390/jcm10092028.
5
Clinical and Pathological Features of Prostatic Stromal Tumor of Uncertain Malignant Potential: A Retrospective Study of 23 Chinese Cases.前列腺间质肿瘤恶性潜能未定的临床病理特征:23 例中国病例的回顾性研究。
Urol Int. 2021;105(3-4):206-214. doi: 10.1159/000508763. Epub 2020 Nov 20.
6
Prostatic stromal proliferations: a review.前列腺基质增生:综述。
Pathology. 2021 Jan;53(1):12-25. doi: 10.1016/j.pathol.2020.09.017. Epub 2020 Nov 13.
7
Demographics, stage distribution, and relative roles of surgery and radiotherapy on survival of persons with primary prostate sarcomas.原发性前列腺肉瘤患者的人口统计学、分期分布以及手术和放疗的相对作用。
Cancer Med. 2018 Dec;7(12):6030-6039. doi: 10.1002/cam4.1872. Epub 2018 Nov 19.
8
Prostatic stromal sarcoma: A case report and literature review.前列腺基质肉瘤:一例病例报告及文献综述
Medicine (Baltimore). 2018 May;97(18):e0495. doi: 10.1097/MD.0000000000010495.
9
Mesenchymal tumors of the prostate.前列腺间质肿瘤。
Mod Pathol. 2018 Jan;31(S1):S133-142. doi: 10.1038/modpathol.2017.155.
10
Whole-exome sequencing demonstrates recurrent somatic copy number alterations and sporadic mutations in specialized stromal tumors of the prostate.全外显子组测序显示前列腺特化性间质肿瘤中存在反复出现的体细胞拷贝数改变和散发性突变。
Hum Pathol. 2018 Jun;76:9-16. doi: 10.1016/j.humpath.2017.12.004. Epub 2017 Dec 16.