Siqueira Raquel Allen Garcia Barbeto, Hradkova Iveta, Leite-Silva Vânia Rodrigues, Andréo-Filho Newton, Lopes Patricia Santos
Programa de Pós-Graduação em Medicina Translacional, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04021-001, Brazil.
Departamento de Ciências Farmacêuticas, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, UNIFESP, Diadema 09913-030, Brazil.
ACS Omega. 2025 Jul 2;10(27):28534-28546. doi: 10.1021/acsomega.4c11687. eCollection 2025 Jul 15.
Skin lipids are essential components that play crucial roles in maintaining the skin barrier, preventing transepidermal water loss, and protecting against external agents. The specific composition of lipids may vary according to factors, such as age, diet, and environmental conditions. They are found predominantly in the stratum corneum, the outermost layer of the epidermis, with lipids originating from epidermal lipids and also from the sebaceous glands. The diversity of lipids, including ceramides, cholesterol, free fatty acids, sphingolipids, phospholipids, triglycerides, and waxes, reflects the complexity of their functions. Understanding the properties and biosynthesis of skin lipids is fundamental for advancing dermatology, developing treatments for various skin conditions, and maintaining the integrity of the skin barrier. Skin microbiome could affect skin lipid composition, and this topic has yet to be completely understood. This literature review aims to understand the properties of lipids found in the skin, the function and importance of fatty acids for skin maintenance and integrity, and their correlations that influence homeostasis: pH, the role of lipids in the microbiota, and finally, daily care practices that can influence the health of the skin and also the microbiome.
皮肤脂质是维持皮肤屏障、防止经表皮水分流失以及抵御外界因素的关键组成部分。脂质的具体成分可能因年龄、饮食和环境条件等因素而有所不同。它们主要存在于表皮最外层的角质层中，脂质来源于表皮脂质以及皮脂腺。脂质的多样性，包括神经酰胺、胆固醇、游离脂肪酸、鞘脂、磷脂、甘油三酯和蜡质，反映了其功能的复杂性。了解皮肤脂质的特性和生物合成对于推动皮肤病学发展、开发各种皮肤疾病的治疗方法以及维持皮肤屏障的完整性至关重要。皮肤微生物群可能会影响皮肤脂质组成，而这一主题尚未完全被理解。这篇文献综述旨在了解皮肤中脂质的特性、脂肪酸对皮肤维持和完整性的功能及重要性，以及它们影响内环境稳态的相关性：pH值、脂质在微生物群中的作用，最后是能够影响皮肤健康以及微生物群的日常护理措施。
