Freund Brin E, Husari Khalil S, Fernández-Torre José L, Gélisse Philippe, Kaplan Peter W
Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA.
Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.
Clin Neurophysiol Pract. 2025 Jun 27;10:265-277. doi: 10.1016/j.cnp.2025.06.001. eCollection 2025.
Generalized periodic discharges (GPDs) with triphasic morphology (triphasic waves, TWs) are EEG waveforms that have been a frequent topic of research evaluating their etiology and clinical correlates. More specifically, prior studies have tried to better elucidate their implications regarding seizures to help guide decision making regarding empiric treatment and EEG monitoring and in spite of multiple studies, controversies remain due to disparate findings. In this review we discuss the historical views of TWs and their clinical and radiographic correlates, highlight the typical and atypical features of TWs, discuss the controversy related to the association between TWs and seizures, and propose an approach to their management.
具有三相形态的广泛性周期性放电（GPDs，三相波，TWs）是脑电图波形，一直是评估其病因和临床相关性的研究热点。更具体地说，先前的研究试图更好地阐明它们与癫痫发作的关系，以帮助指导经验性治疗和脑电图监测的决策，尽管有多项研究，但由于结果不一，争议仍然存在。在本综述中，我们讨论了三相波的历史观点及其临床和影像学相关性，强调了三相波的典型和非典型特征，讨论了与三相波和癫痫发作关联相关的争议，并提出了其管理方法。
