Citron Chloe, Erkman Jessica, Kazachkov Mikhail, Nowak-Wegrzyn Anna, Kesebir Deniz
Department of Pediatrics, Hassenfeld Children's Hospital, NYU Grossman School of Medicine, NYU Langone Health, New York, USA.
Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
Respir Med Case Rep. 2025 Jun 30;57:102246. doi: 10.1016/j.rmcr.2025.102246. eCollection 2025.
We present two pediatric patients with severe uncontrolled asthma who underwent aerodigestive evaluation revealing eosinophilic asthma and eosinophilic esophageal inflammation. They were subsequently initiated on targeted biological therapy for eosinophilic inflammation with dupilumab resulting in clinical and histological improvement. These cases demonstrate that aerodigestive evaluation is an important clinical tool for characterizing asthma phenotypes and diagnosing comorbidities in children with SUA to optimize their treatment regimens.
我们报告了两名患有严重难治性哮喘的儿科患者，他们接受了气道消化道评估，结果显示为嗜酸性粒细胞性哮喘和嗜酸性粒细胞性食管炎。随后，他们开始接受针对嗜酸性粒细胞炎症的靶向生物治疗，使用度普利尤单抗，临床和组织学均有改善。这些病例表明，气道消化道评估是一种重要的临床工具，可用于明确重度未控制哮喘儿童的哮喘表型和诊断合并症，以优化其治疗方案。
