Bouayed Fatima Zahra, Berhili Soufiane, El-Masadi Mohammed, El Magroud Mohammed, BenSghier Ahmed, Moukhlissi Mohamed, Mezouar Loubna
Radiation Oncology, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, MAR.
Pathology, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, MAR.
Cureus. 2025 Jun 18;17(6):e86323. doi: 10.7759/cureus.86323. eCollection 2025 Jun.
The hobnail variant of papillary thyroid carcinoma (HPTC) is a rare but highly aggressive form of thyroid cancer, associated with a more severe clinical course and significantly poorer prognosis compared to conventional PTC. To be classified as HPTC, a tumor must contain at least 30% of cells exhibiting hobnail-micropapillary features. These cells are characterized by distinctive papillary cytomorphology, including a hobnail-like appearance, the presence of papillae and micropapillae, high nuclear-to-cytoplasmic ratios, apically located nuclei, and prominent nucleoli. Additionally, some studies have reported associations between HPTC and specific genetic mutations, such as BRAFV600E, TP53, and TERT. In this article, we present the case of a 58-year-old male diagnosed with HPTC, managed with radiotherapy.
甲状腺乳头状癌的鞋钉样变体（HPTC）是一种罕见但侵袭性很强的甲状腺癌，与传统乳头状甲状腺癌（PTC）相比，其临床病程更严重，预后明显更差。要被归类为HPTC，肿瘤必须包含至少30%表现出鞋钉样微乳头特征的细胞。这些细胞具有独特的乳头状细胞形态，包括鞋钉样外观、乳头和微乳头的存在、高核质比、位于顶端的细胞核以及明显的核仁。此外，一些研究报告了HPTC与特定基因突变之间的关联，如BRAFV600E、TP53和TERT。在本文中，我们介绍了一名58岁男性被诊断为HPTC并接受放射治疗的病例。
