Oldham Eli P, Bobkova Svetlana, Loykasek Patti, Roberts Jennifer, Shendrik Igor
Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, USA.
National Center for Wellness and Recovery, Oklahoma State University Center for Health Sciences, Tulsa, USA.
Cureus. 2025 Jun 19;17(6):e86361. doi: 10.7759/cureus.86361. eCollection 2025 Jun.
Epithelioid fibrous histiocytoma (EFH) is a benign fibrohistiocytic neoplasm characterized by morphologic heterogeneity and recurrent anaplastic lymphoma kinase () gene rearrangements. We present a rare case of EFH located on the lateral neck of a 56-year-old male patient, demonstrating a predominantly spindle cell morphology. Immunohistochemical analysis revealed granular cytoplasmic positivity for ALK, along with expression of CD68, CD4, epithelial membrane antigen, caldesmon, and smooth muscle actin. Next-generation sequencing confirmed the presence of a rare fusion. The presented case highlights a predominantly spindle cell variant of EFH and suggests inclusion within the recently described myxoid spindle cell EFH spectrum, which encompasses the superficial ALK-rearranged myxoid spindle cell neoplasms (SAMS).
上皮样纤维组织细胞瘤（EFH）是一种良性纤维组织细胞肿瘤，其特征为形态学异质性和间变性淋巴瘤激酶（ALK）基因重排复发。我们报告一例罕见的位于56岁男性患者侧颈部的EFH，主要表现为梭形细胞形态。免疫组化分析显示ALK呈颗粒状胞质阳性，同时表达CD68、CD4、上皮膜抗原、钙调蛋白和平滑肌肌动蛋白。二代测序证实存在罕见的 融合。该病例突出了EFH的主要梭形细胞变体，并提示应纳入最近描述的黏液样梭形细胞EFH谱系，该谱系包括浅表ALK重排的黏液样梭形细胞肿瘤（SAMS）。
