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全血细胞减少症揭秘:将罕见的人心杆菌菌血症追溯至肠道

Pancytopenia Unraveled: Tracing Rare Cardiobacterium hominis Bacteremia Back to the Gut.

作者信息

Kleynerman Annie, Day Ryan C, Honkanen Iiro

机构信息

Department of Medicine, Medical College of Wisconsin, Milwaukee, USA.

Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, USA.

出版信息

Cureus. 2025 Jun 19;17(6):e86358. doi: 10.7759/cureus.86358. eCollection 2025 Jun.

Abstract

() is part of the normal flora of the human oropharynx. Although uncommon, it is a significant cause of endocarditis, particularly in individuals with pre-existing valvular heart disease. The combination of its rarity, prolonged blood culture incubation time, and nonspecific clinical presentation makes  infections particularly challenging to diagnose. We present the first known published case of pancytopenia secondary to  bacteremia in an elderly male, likely incited by a gastrointestinal endoscopic procedure. We discuss the importance of recognizing signs of subclinical bacteremia and maintaining a broad differential for pancytopenia for timely diagnosis and management.

摘要

()是人类口咽正常菌群的一部分。虽然不常见,但它是心内膜炎的重要病因,尤其是在已有瓣膜性心脏病的个体中。其罕见性、血培养孵育时间延长以及非特异性临床表现使得()感染的诊断极具挑战性。我们报告了首例已知的老年男性因()菌血症继发全血细胞减少的病例,可能是由胃肠道内镜检查引发的。我们讨论了识别亚临床菌血症迹象以及对全血细胞减少保持广泛鉴别诊断以实现及时诊断和管理的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb46/12275982/ea4192863c3e/cureus-0017-00000086358-i01.jpg

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