Du Lanxiang, Guan Chengyan, Zhang Hao, Jia Haoyue, Wan Qiang
Department of Traumatic Orthopedics, Ganzhou Traditional Chinese Medicine Hospital Affiliated to Jiangxi University of Chinese Medicine, Ganzhou, China.
Clinical Medical College, Jiangxi University of Chinese Medicine, Nanchang, China.
Front Pharmacol. 2025 Jul 4;16:1620152. doi: 10.3389/fphar.2025.1620152. eCollection 2025.
Cardiovascular diseases (CVDs) have emerged as one of the leading causes of global mortality and health burden, with their prevalence and mortality rates demonstrating a persistent upward trend, thereby posing significant challenges to public health worldwide. Tanshinone IIA (Tan IIA), the principal lipophilic bioactive component isolated from , has gained substantial recognition in cardiovascular therapeutics. Accumulating evidence from recent investigations has demonstrated that Tan IIA exhibits multi-target pharmacological properties and modulates diverse signaling pathways in cardiovascular protection, positioning it as a promising candidate in natural product-based drug discovery. The therapeutic efficacy is mediated through multiple mechanisms, including but not limited to anti-atherosclerotic effects, lipid homeostasis regulation, anti-arrhythmic properties, myocardial functional enhancement, and hemodynamic stabilization. This comprehensive review systematically elucidates the molecular mechanisms and therapeutic targets underlying Tan IIA's cardio-protective effects, particularly focusing on its anti-inflammatory, antioxidant, anti-atherosclerotic, and myocardial preservation properties. Furthermore, we critically evaluate its current clinical applications and propose potential directions for future research to optimize its therapeutic potential in cardiovascular medicine.
心血管疾病（CVDs）已成为全球死亡和健康负担的主要原因之一，其患病率和死亡率呈持续上升趋势，给全球公共卫生带来了重大挑战。丹参酮IIA（Tan IIA）是从丹参中分离出的主要亲脂性生物活性成分，在心血管治疗领域已获得广泛认可。最近的研究积累的证据表明，Tan IIA具有多靶点药理特性，并在心血管保护中调节多种信号通路，使其成为基于天然产物的药物发现中有前景的候选药物。其治疗效果是通过多种机制介导的，包括但不限于抗动脉粥样硬化作用、脂质稳态调节、抗心律失常特性、心肌功能增强和血流动力学稳定。这篇综述系统地阐明了Tan IIA心脏保护作用的分子机制和治疗靶点，特别关注其抗炎、抗氧化、抗动脉粥样硬化和心肌保护特性。此外，我们批判性地评估了其目前的临床应用，并提出了未来研究的潜在方向，以优化其在心血管医学中的治疗潜力。
