Perkins Lynda S, Nugent Anne P, Woodside Jayne V, Cardwell Chris R, Scollan Nigel D
The Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 19 Chlorine Gardens, Belfast, BT9 5DL, Northern Ireland, UK.
Institute of Food and Health, School of Agriculture and Food Science, University College Dublin, Dublin, D04 V1W8, Ireland.
Eur J Nutr. 2025 Jul 21;64(5):242. doi: 10.1007/s00394-025-03765-z.
Dietary intakes of omega-3 polyunsaturated fatty acids (ω-3 PUFA) are below what is recommended. Meat from grass finished ruminants contains higher levels of ω-3 PUFAs, particularly, alpha-linolenic acid (C18:3 ω-3). The impact of consuming grass finished lamb meat rich in ω-3 PUFA on blood fatty acid (FA) response in humans is not well established. This study investigated the impact of consuming grass finished lamb on total blood plasma and blood plasma phospholipids (PL) FA and on cardiovascular risk factors, including heart rate, blood pressure (BP), HDL, LDL, total cholesterol, and TAG, in humans.
A single blinded, randomised controlled trial was conducted. Two portions of lamb chops and one portion of lamb mince from lambs finished on a grass or concentrate diet were consumed per week by 34 healthy participants for four consecutive weeks. Blood samples were taken at baseline and post-intervention. Approximately ~ 328 mg/100 g of total ω-3 PUFA was present in grass finished lamb portions per week.
Greater levels of ω-3 PUFA, namely C18:3 ω-3, eicosapentaenoic acid (C20:5 ω-3) and docosapentaenoic acid (C22:5 ω-3), were detected in total blood plasma from participants who consumed grass finished lamb (P < 0.05), while consuming concentrate finished lamb higher levels of linoleic acid (C18:2 ω-6) in plasma PL (P < 0.01). There were no differences of consuming grass or concentrate finished lamb on cardiovascular risk factors.
This study demonstrates that ω-3 PUFA from lamb meat finished on grass is reflected in blood ω-3 PUFA response. Grass finished lamb is a useful matrix for increasing intake of ω-3 PUFA into the human body alongside little required change to customary dietary habits.
gov ID: NCT06607354. Retrospectively registered 24/09/2024.
ω-3多不饱和脂肪酸（ω-3 PUFA）的膳食摄入量低于推荐水平。草饲反刍动物的肉中ω-3 PUFA含量较高，尤其是α-亚麻酸（C18:3 ω-3）。食用富含ω-3 PUFA的草饲羊肉对人体血液脂肪酸（FA）反应的影响尚未明确。本研究调查了食用草饲羊肉对人体全血血浆和血浆磷脂（PL）FA以及心血管危险因素（包括心率、血压（BP）、高密度脂蛋白、低密度脂蛋白、总胆固醇和甘油三酯）的影响。
进行了一项单盲随机对照试验。34名健康参与者连续四周每周食用两份草饲或精饲羔羊的羊排和一份羊绞肉。在基线和干预后采集血样。每周草饲羊肉部分中约含有~328 mg/100 g的总ω-3 PUFA。
食用草饲羊肉的参与者全血血浆中检测到较高水平的ω-3 PUFA，即C18:3 ω-3、二十碳五烯酸（C20:5 ω-3）和二十二碳五烯酸（C22:5 ω-3）（P<0.05），而食用精饲羊肉的参与者血浆PL中亚油酸（C18:2 ω-6）水平较高（P<0.01）。食用草饲或精饲羊肉对心血管危险因素没有差异。
本研究表明，草饲羊肉中的ω-3 PUFA反映在血液ω-3 PUFA反应中。草饲羊肉是一种有用的载体，可在对习惯饮食习惯几乎无需改变的情况下增加人体对ω-3 PUFA的摄入量。
gov ID：NCT06607354。2024年9月24日进行回顾性注册。
