David Helma, Nithya Kesavan, Shankar Salian Lavanya, Dandela Rambabu, Suresh Devarajan, Amali Arlin Jose, Solomon Adline Princy
School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur 613401, India.
Research Scholar, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu 625 021, India.
ACS Appl Bio Mater. 2025 Sep 15;8(9):7715-7727. doi: 10.1021/acsabm.5c00559. Epub 2025 Jul 21.
The recent advancements in nanotechnology have brought about significant improvements and transformations in the field of biomedicine, particularly in the areas of biodetection, drug delivery, and diagnostic imaging. Among the various materials being developed, porous crystalline polymers have shown great promise for these applications. Covalent Organic Frameworks (COFs) have been attractive because of their very high porosity, extended surface area, and thermal stability, making them very promising in the development of antimicrobial and antifungal therapies. In the present study, we successfully synthesized and characterized the Covalent Triazine Framework (CTF) to examine its potential as an antifungal agent against . The synthesized CTF-III has very low levels of toxicity and demonstrates antifungal activity with MIC values ranging between 0.2 and 0.4 mg/mL against various strains of . Furthermore, CTF-III effectively eliminates established biofilms at concentrations as low as 0.2 mg/mL. Moreover, CTF-III exhibits impressive efficacy in targeting persister cells within the biofilms, which are highly resistant to conventional antifungal treatments available in the market. CTF-III is a promising material for improving biological applications, such as coatings for medical devices and drug delivery systems, due to its stability, biocompatibility, and mechanical properties. Additionally, this material has the potential to lead to the development of antifungal agents and help address the challenges posed by emerging resistance to antifungals.
纳米技术的最新进展给生物医学领域带来了显著的改进和变革，尤其是在生物检测、药物递送和诊断成像等方面。在正在研发的各种材料中，多孔结晶聚合物在这些应用中显示出了巨大的潜力。共价有机框架（COF）因其极高的孔隙率、大的表面积和热稳定性而备受关注，这使得它们在抗菌和抗真菌疗法的开发中非常有前景。在本研究中，我们成功合成并表征了共价三嗪框架（CTF），以研究其作为抗真菌剂针对……的潜力。合成的CTF - III毒性水平极低，对各种……菌株的最低抑菌浓度（MIC）值在0.2至0.4 mg/mL之间，显示出抗真菌活性。此外，CTF - III在低至0.2 mg/mL的浓度下就能有效消除已形成的生物膜。而且，CTF - III在靶向生物膜内对市场上现有传统抗真菌治疗具有高度抗性的持留菌方面表现出令人印象深刻的效果。由于其稳定性、生物相容性和机械性能，CTF - III是一种用于改善生物应用（如医疗设备涂层和药物递送系统）的有前景的材料。此外，这种材料有可能推动抗真菌剂的开发，并有助于应对新出现的抗真菌耐药性带来的挑战。
